Alpha Lipoic Acid
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Alpha Lipoic Acid

Product name: Alpha Lipoic Acid
CAS No.: 62-46-4
MW: 206.3182
MF: C8H14O2S2
Test method: HPLC
Appearance:Yellow Powder

Alpha lipoic acid description

Lipoic acid is an organic compound, which can be used as a coenzyme to participate in the acyl transfer of material metabolism in the body, and can eliminate the free radicals that cause accelerated aging and disease. Lipoic acid enters cells after intestinal absorption in vivo, which has the characteristics of fat solubility and water solubility.

As a coenzyme, lipoic acid plays a role in two key oxidative decarboxylation reactions, namely, in the pyruvate dehydrogenase complex and α- Ketoglutarate dehydrogenase complexes catalyze the production and transfer of acyl groups. Lipoic acid can accept the acetyl group of acyl and pyruvic acid, forming a thioester bond, and then transfer the acetyl group to the sulfur atom of the coenzyme A molecule. The dihydrolipoctamide forming the auxiliary group can be oxidized by dihydrolipoctamide dehydrogenase (requiring NAD+) to regenerate oxidized lipoctamide. α- Lipoic acid contains a disulfide pentamembered ring structure with a high electron density, significant electrophilicity, and the ability to react with free radicals. Therefore, it has antioxidant properties, high health functions, and medical value (such as anti fatty liver and lowering plasma cholesterol). In addition, the sulfhydryl group of lipoic acid is easily subjected to oxidation-reduction reactions, thereby protecting the sulfhydryl enzyme from the toxicity of heavy metal ions. Lipoic acid is widely distributed in nature, especially in liver and yeast cells. In foods, lipoic acid is often present simultaneously with vitamin B1. The human body can synthesize. No human lipoic acid deficiency has been detected.

Alpha lipoic acid efficacy and function

Lipoic acid, also known as α- Lipoic acid, specifically a naturally occurring form in nature, was first isolated from pig liver by Reed in 1951. Lipoic acid is a disulfide compound of a type of vitamin, commonly considered a B vitamin. Lipoic acid is an important coenzyme in organisms, an important cofactor for pyruvate dehydrogenase, ketoglutarate dehydrogenase, and aminocaproic acid dehydrogenase, and is one of the indispensable substances in the tricarboxylic acid cycle. The human body is able to synthesize sufficient amounts of lipoic acid on its own, and there have been no cases of lipoic acid deficiency. However, in the study, it was found that lipoic acid supplementation in vitro can inhibit lipid oxidation of nerve tissue, prevent protein glycosylation, inhibit aldose reductase, and prevent glucose or galactose from transforming into sorbitol. It is used as a drug to treat diabetes neuropathy or neurological complications in Europe.

In addition to the role of coenzyme, lipoic acid also has a strong antioxidant function, which can eliminate free radicals that lead to accelerated aging and disease. It has a variety of functions such as anti-oxidation, anti-aging, improving immunity, preventing cardiovascular disease, and alleviating diabetes symptoms.

Alpha lipoic acid function and application

1. Lipoic acid has the function of strengthening liver activity, so it was also used as an antidote for food poisoning or metal poisoning in the early stage.

2. Lipoic acid can improve the energy metabolism rate and effectively convert the food into energy, so it can quickly eliminate fatigue.

3. Lipoic acid is one of the few nutrients that can reach the brain. It also has sustained antioxidant activity in the brain and is considered to be quite effective in improving dementia.

4. Lipoic acid has the function of nourishing, beautifying and anti-aging.