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Product name:Ceramide
CAS No.:104404-17-3
Molecular Formula:C34H66NO3R
Molecular weight:536.89
EINECS NO.: 309-560-3
Appearance:White Powder

Ceramide description

Ceramide is an amide compound formed by dehydration of the amino groups of long-chain fatty acids and sphingosine, mainly including ceramide choline phosphate and ceramide ethanolamine phosphate. Phospholipids are the main components of the cell membrane. 40%~50% of the sebum in the stratum corneum is composed of ceramide. Ceramide is the main part of the intercellular matrix and plays an important role in maintaining the water balance of the stratum corneum. Ceramide has a strong ability to bind water molecules. It maintains skin moisture by forming a network structure in the stratum corneum. Therefore, ceramide has the function of keeping skin moisture.

Ceramide main functions

1. Barrier effect

Experimental studies have shown that ceramide plays a very important role in maintaining skin barrier function.

2. Adhesion

Experimental studies have shown that ceramide content is directly related to the degree of skin dryness. The use of ceramide can significantly enhance the adhesion between keratinocytes, improve skin dryness, and reduce skin desquamation.

3. Moisturizing effect

Ceramide has a strong ability to associate water molecules, maintaining skin moisture by forming a network structure in the stratum corneum. Therefore, ceramide has a moisturizing effect on the skin.

4. Anti aging effect

Ceramide can improve skin dryness, desquamation, roughness, and other conditions; At the same time, ceramide can increase the thickness of the epidermal cuticle, improve the skin's water holding capacity, reduce wrinkles, enhance skin elasticity, and delay skin aging.

5. Cell function

Some experimental studies have shown that ceramide has cell functions such as regulating cell growth variability and inducing apoptosis.

Ceramide main applications

1. Daily chemical aspects

The use of skin activating essence cosmetics containing neurophthalamide can strengthen the anti-aging function of the skin, keep the skin elastic, smooth and delicate, and reduce the formation of facial wrinkles.

2. Medical aspects

Ceramide plays an important messenger role in inducing biological effects such as various cytokines, vitamin D3, Fas, and CD28 ligands, and its role in mediating cell apoptosis has received increasing attention; Ceramide is also involved in various physiological and pathological processes such as cell differentiation. Ceramide can induce apoptosis during the culture of epidermal keratinocytes. Ceramide is a decomposition product of sphingomyelin in the bilayer of biofilms and is recognized as the second messenger; Ceramide plays a wide and important role in the growth, proliferation, differentiation, apoptosis, and injury of cells.

3. Food industry

Many health foods have been developed using some physiological functions of ceramide, such as inhibiting blood pressure rise, activating immunity, inhibiting lipase activity, and inhibiting cancer cell proliferation.

Ceramide preparation method

1. Natural extraction method

The naturally extracted ceramide comes from animals and plants. Animals are derived from the brain of animals with a risk of disease, so they cannot be used in cosmetics. Plant extraction methods are limited by plant growth cycles and seasons, resulting in low yields.

2. Chemical synthesis method

The main chemical synthesis is ceramidoids, which are similar in structure and function to ceramides and can be used in cosmetics. Many ceramidoids have been successfully synthesized.

3. Microbial fermentation method

Microbial fermentation is a commonly used method for the preparation of ceramide in recent years, which uses Pichia pastoris or Saccharomyces cerevisiae to ferment under certain conditions to obtain tetraacetyl plant sphingosine (TAPS), then deacetylates it to obtain plant sphingosine, and adds fatty acids to synthesize ceramide and other substances.