Epigallocatechin Gallate (egcg)
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Epigallocatechin Gallate (egcg)

Product name: Epigallocatechin Gallate (egcg)
CAS No.:989-51-5
Molecular Formula: C22H18O11
Molar mass: 458.372 g/mol
Storage: Well-closed, dry place with constant 2-8℃

Epigallocatechin gallate description

Epigallocatechin gallate is the most effective active component in tea polyphenols, belonging to catechins. EGCG has antibacterial, antiviral, antioxidant, anti atherosclerotic, antithrombotic, anti vascular proliferation, anti-inflammatory, and anti-tumor effects. There is EGCG in green tea, but not in black tea. Because the EGCG in black tea is converted into Thearubigin. EGCG has the functions of preventing and treating various diseases such as cancer and enhancing immunity in medicine and health care; In the food industry, it can be used as an antioxidant, bacteriostatic, fresh-keeping, deodorant; It is used as a quality assurance agent and skin care agent with special functions in daily chemical products.

Epigallocatechin gallate effect

Epigallocatechin gallate (EGCG) is a component extracted from Chinese green tea. It is the main active and water-soluble component of green tea and the highest content of catechin, accounting for 9% to 13% of the gross weight of green tea, due to its special stereochemical structure, EGCG has very strong antioxidant activity, which is at least 100 times higher than vitamin C and 25 times higher than vitamin E, and can protect cells and DNA from damage. This damage is believed to be related to cancer, heart disease, and other major diseases. These effects of EGCG are attributed to their ability to scavenge (antioxidant) oxygen free radicals.

Epigallocatechin gallate plays an important role in the fight against cancer and cardiovascular disease. In addition, it is also used as a reversal agent for multidrug resistance in tumors, which can improve the sensitivity of cancer cells to chemotherapy and reduce their toxicity to the heart.

EGCG is the main component of green tea polyphenols, as well as the main component of green tea catechins, which include EGCG, EGC, ECG, EC, GCG, and so on. The antioxidant activity in turn is EC. Many studies have shown that EGCG has the ability to resist free radical DNA damage, resist radiation, and ultraviolet rays, prevent lipid peroxidation, reduce the content of low density cholesterol, ultra-low density cholesterol, and triglycerides in serum, and interfere with signal transmission required for cancer cell survival, Inhibit carcinogens in the diet, work with other enzymes and antioxidants in the intestine, liver, and lungs to block the activity of certain carcinogens, remove free radicals, resist the effects of pollution, sunlight, and smoking, and prevent skin aging and wrinkling.

Epigallocatechin gallate application

1. In medicine and health care, it has the functions of preventing and treating various diseases such as cancer and enhancing immunity

The anti tumor effect of EGCG has been recognized by relevant researchers around the world, and has been listed as a potential new anti cancer drug for research in many countries such as China and the United States. A large number of clinical medical experiments have proven that EGCG is no less toxic than paclitaxel in the treatment of various cancers, and its toxicity is far lower than that of paclitaxel. In particular, there are many reports on the application of skin cancer research, which has now entered the clinical stage. It can be said that it is an effective, non-toxic and ideal drug for the treatment of cancer, with great development value.

The pharmacological effects of EGCG mainly include: ⑴ inhibiting the invasion and metastasis of tumor cells; ⑵ Regulating the metabolic process of tumor initiators; ⑶ Regulate carcinogenic metabolic enzymes; (4) Inhibition of covalent binding of oncogenes and DNA; ⑸ Inhibiting the proliferation process of tumor cells; (6) Inhibiting the nitrification process; (7) It has significant antioxidant, free radical scavenging, and antimutagenic effects. It can enhance the function of the immune system, inhibit the growth of liver fat and cholesterol, and inhibit the growth of tumors. It also has a strong inhibitory effect on bacteria such as dysentery, typhoid, and Staphylococcus aureus.

EGCG also has the functions of anti-aging, reducing blood fat, improving low-density lipoprotein, preventing atherosclerosis, and enhancing immunity; It can inhibit the proliferation of glomerular cell membrane and improve renal function; Effectively inhibit hyaluronidase, reduce inflammation and allergic reactions.

2. It can be used as an antioxidant, bacteriostatic, fresh-keeping, deodorant in the food industry

3. Used as a quality assurance agent and skin care agent with special functions in daily chemical products

At room temperature, low concentration EGCG has strong antioxidant, free radical elimination, sterilization, and odor removal functions. Therefore, adding a small amount of EGCG can prevent the deterioration of cosmetics. As a natural biochemical raw material for cosmetics, EGCG has the following characteristics compared to other biochemical raw materials: low molecular weight, extremely easy to be absorbed by human skin, and good transdermal absorption performance; The activity is extremely stable, and temperature has minimal impact on its activity. Under acidic and closed light conditions, the activity remains unchanged for a long time; It is safe and reliable, and has been inspected by relevant professional institutions. Its toxicological determination and micronucleus test indicate that it is non-toxic and non irritant, and meets the quality standards for daily chemical products; Small dosage, strong effect; It has strong antioxidant activity, with an antioxidant capacity 2-4 times that of DHA and BHT, and is effective at low concentrations.

The role of EGCG in cosmetics can be summarized as follows: ⑴ anti wrinkle and beauty effects; ⑵ Sunscreen and spot removing effect; ⑶ Relieve toxic effects of heavy metals; ⑷ Antimicrobial and anti-inflammatory effects; (5) Promote skin microcirculation, etc.; (6) Anti skin cancer; (7) Can eliminate skin freckles and yellow spots, making the skin smooth.