Ethyl Oleate (medicinal Excipients)
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Ethyl Oleate (medicinal Excipients)

Product Name: Ethyl oleate (medicinal excipients)
Alias: (Z)-9-Octadecenoic acid ethyl ester
CAS NO.: 111-62-6
Molecular formula: C20H38O2
Molecular weight: 310.51
EINECS NO.: 203-889-5
Appearance:Colorless to yellowish oily liquid.

Ethyl oleate chemical property

Colorless to light yellow oily liquid. It smells like flowers. Boiling point 205-208 ℃. Insoluble in water, soluble in ethanol and acetaldehyde.

Ethyl oleate function and application

1. It can be used as lubricant, water-resistant agent and resin toughening agent.

2. It can be used for the preparation of surfactants and other organic chemicals. It is also used as perfume, pharmaceutical excipient, plasticizer and ointment matrix.

Ethyl oleate production method

It is prepared by esterification of ethanol and oleic acid. Mix oleic acid and ethanol, add catalyst concentrated sulfuric acid or p-toluenesulfonic acid, heat and reflux. Cool, neutralize with alkali to pH value of 8-9, wash with water to neutral, dry with anhydrous calcium chloride, conduct vacuum distillation, and intercept the ethyl oleate fraction. Mesoporous molecular sieve SBA-15-SO3 can also be used as a catalyst, the molar ratio of methanol to oleic acid is excessive, heated, refluxed at a temperature of 130°C for 4 hours, cooled, filtered, distilled, and ethyl oleate fraction is intercepted to obtain ethyl oleate.

Ethyl oleate can also be obtained by transesterification of another oleic acid ester with ethanol.

Ethyl oleate common chemical reactions

Ethyl oleate is a kind of fatty acid ester, so it has the common reaction properties of fatty acid ester, mainly including:

(1) Hydrolysis reaction: ethyl oleate hydrolyzes in the presence of acid catalyst to produce a reaction equilibrium mixture of oleic acid, ethanol, ethyl hydrooleate, etc. When alkali is used as catalyst, the product is oleate, and the reaction is irreversible, also called saponification reaction. In addition, it can also be hydrolyzed by high-pressure steam at 185~300 ℃ to produce oleic acid and methanol.

(2) Aminolysis, alcoholysis and ester exchange reaction: the reaction of ethyl oleate and ammonia to produce oleic amide and ethanol, and the reaction with other fatty alcohols other than ethanol to produce new oleic ester and ethanol. Ethyl oleate reacts with another ester, and the ester group exchanges to form a new oleate and carboxylate. The above reactions can be accelerated by the presence of acid, alkali and other catalysts.