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(1) Hesperidin is a drug for treating hypertension and myocardial infarction. It is used as a raw material in the pharmaceutical industry and is one of the main components of Maitong, a Chinese patent medicine.
(2) Hesperidin has the effects of anti lipid oxidation, scavenging oxygen free radicals, anti inflammation, anti-virus and anti-bacterial. Long term use can delay aging and anti-cancer. In a word, hesperidin is a flavonoid compound with exact pharmacological activity and extensive functions. Besides its medical use, it also has a wide range of uses in sports pharmacy and sports nutrition. Therefore, it has broad prospects for development and utilization. Its related research work is expected to be further in-depth and systematic.
Hesperidin has the functions of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time, lowering cholesterol, etc. It is clinically used as an auxiliary treatment for cardiovascular diseases, it can cultivate a variety of drugs to prevent arteriosclerosis and myocardial infarction, and it is one of the main raw materials of the patent medicine "Maitong". It can be used as a natural antioxidant in the food industry. It can also be used in the cosmetics industry.
Relevant research shows that hesperidin has broad-spectrum antibacterial effect on common food contaminating bacteria, and it has significant inhibitory effect on Bacillus subtilis, Salmonella typhimurium, Shigella flexneri, Streptococcus hemolyticus and Vibrio cholerae. Therefore, hesperidin is widely used in food additives and food processing.
Most hesperidin is found in the waste of citrus processing. If it is in the peel and fruit sac, the content of hesperidin in the mature peel and tissue is the highest (30% - 50% in the inner peel, 30% - 50% in the orange pulp, stone and pulp, and 10% - 20% in the outer peel), and the content in juice and orange sac is 1% - 5% lower. The extraction methods of hesperidin include solvent extraction, alkali extraction and acid precipitation, carbon powder adsorption, and ion exchange. Among them, alkali extraction and acid precipitation are simple in operation, low in cost, and high in extraction rate. Hesperidin is soluble in dilute alkali, pyridine and hot water above 70 ℃, slightly soluble in methanol, almost insoluble in acetone, benzene and chloroform.
The extraction of hesperidin is mainly to use the two phenol hydroxyl groups contained in hesperidin to react with sodium ions in solution under alkaline conditions to generate sodium salt and dissolve it, then acidification and cooling to separate it from the solution. The extraction of hesperidin from citrus peel generally adopts heat extraction and soaking extraction, and the yield is not ideal. In recent years, the research on ultrasonic extraction of effective components from natural plants (especially Chinese herbal medicine) has been widely carried out and made some progress. Hesperidin is extracted by ring opening dissolution under alkaline conditions, and separated by closed-loop precipitation under acidic conditions. Increasing the amount of alkali during extraction can reduce the amount of ethanol, but the alkalinity should not be too large, otherwise Hesperidin is easy to be oxidized and destroyed.
(1) Hesperidin is a drug for treating hypertension and myocardial infarction. It is used as a raw material in the pharmaceutical industry and is one of the main components of Maitong, a Chinese patent medicine.
(2) Hesperidin has the effects of anti lipid oxidation, scavenging oxygen free radicals, anti inflammation, anti-virus and anti-bacterial. Long term use can delay aging and anti-cancer. In a word, hesperidin is a flavonoid compound with exact pharmacological activity and extensive functions. Besides its medical use, it also has a wide range of uses in sports pharmacy and sports nutrition. Therefore, it has broad prospects for development and utilization. Its related research work is expected to be further in-depth and systematic.
Hesperidin has the functions of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time, lowering cholesterol, etc. It is clinically used as an auxiliary treatment for cardiovascular diseases, it can cultivate a variety of drugs to prevent arteriosclerosis and myocardial infarction, and it is one of the main raw materials of the patent medicine "Maitong". It can be used as a natural antioxidant in the food industry. It can also be used in the cosmetics industry.
Relevant research shows that hesperidin has broad-spectrum antibacterial effect on common food contaminating bacteria, and it has significant inhibitory effect on Bacillus subtilis, Salmonella typhimurium, Shigella flexneri, Streptococcus hemolyticus and Vibrio cholerae. Therefore, hesperidin is widely used in food additives and food processing.
Most hesperidin is found in the waste of citrus processing. If it is in the peel and fruit sac, the content of hesperidin in the mature peel and tissue is the highest (30% - 50% in the inner peel, 30% - 50% in the orange pulp, stone and pulp, and 10% - 20% in the outer peel), and the content in juice and orange sac is 1% - 5% lower. The extraction methods of hesperidin include solvent extraction, alkali extraction and acid precipitation, carbon powder adsorption, and ion exchange. Among them, alkali extraction and acid precipitation are simple in operation, low in cost, and high in extraction rate. Hesperidin is soluble in dilute alkali, pyridine and hot water above 70 ℃, slightly soluble in methanol, almost insoluble in acetone, benzene and chloroform.
The extraction of hesperidin is mainly to use the two phenol hydroxyl groups contained in hesperidin to react with sodium ions in solution under alkaline conditions to generate sodium salt and dissolve it, then acidification and cooling to separate it from the solution. The extraction of hesperidin from citrus peel generally adopts heat extraction and soaking extraction, and the yield is not ideal. In recent years, the research on ultrasonic extraction of effective components from natural plants (especially Chinese herbal medicine) has been widely carried out and made some progress. Hesperidin is extracted by ring opening dissolution under alkaline conditions, and separated by closed-loop precipitation under acidic conditions. Increasing the amount of alkali during extraction can reduce the amount of ethanol, but the alkalinity should not be too large, otherwise Hesperidin is easy to be oxidized and destroyed.
