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Hydroxycobalamin (OHCbl, or B12a) is a natural form of vitamin B12, or one of vitamin B12. It is a basic member of cobaltamine group compounds. Many vitamin producing bacteria used for commercial production produce vitamin B12 in the form of hydroxycobalamin. Hydroxycobalamin is dark red. Vitamin B12 in human body does not usually exist in the form of hydroxycobalamin. However, in human body, hydroxycobalamin is easily converted into the useful coenzyme form of vitamin B12. The medicinal hydroxycobalamin product is its sterile injection, which is used to treat vitamin deficiency and cyanide poisoning (because it is compatible with cyanide ion). Hydroxycobalamin has also been used as a nitric oxide scavenger.
Vitamin B12 refers to a group of compounds called cobaltamine, most of which can be converted into each other in the human body. Hydroxylamine and folic acid together constitute the cofactors necessary for DNA synthesis in cells during chromosome replication and cell division. Most of them exist in bone marrow cells. As a cofactor, cobaltamine is necessary for biochemical reactions in two kinds of cells:
(1) The mitochondrial methylmalonyl coenzyme A methylate mutase converts methylmalonic acid (MMA) into succinate, which is related to the metabolism of lipids and carbohydrates;
(2) Activation of methionine synthetase, which is the rate-limiting step of methionine synthesis from homocysteine and 5-methyltetrahydrofolate.
Hydroxycobalamin is an intermediate for the synthesis of nitrocobalamin and a useful intermediate for the synthesis of cobalamin acetate; Physiological analogue of vitamin B12, in which the CN group is replaced by OH. It exists in aqueous solution as an equilibrium mixture of hydroxyl isomer and ionic water isomer (aquacobalamin). Coenzyme methylcobalamin and precursor of cobalamin. Coordination compounds. Vitamins (hematopoiesis).
It can be used for pernicious anemia and other diseases caused by vitamin B12 deficiency. It can be used in large doses as an antidote for cyanide to convert cyanide into cyanocobalamine.
Hydroxycobalamin (OHCbl, or B12a) is a natural form of vitamin B12, or one of vitamin B12. It is a basic member of cobaltamine group compounds. Many vitamin producing bacteria used for commercial production produce vitamin B12 in the form of hydroxycobalamin. Hydroxycobalamin is dark red. Vitamin B12 in human body does not usually exist in the form of hydroxycobalamin. However, in human body, hydroxycobalamin is easily converted into the useful coenzyme form of vitamin B12. The medicinal hydroxycobalamin product is its sterile injection, which is used to treat vitamin deficiency and cyanide poisoning (because it is compatible with cyanide ion). Hydroxycobalamin has also been used as a nitric oxide scavenger.
Vitamin B12 refers to a group of compounds called cobaltamine, most of which can be converted into each other in the human body. Hydroxylamine and folic acid together constitute the cofactors necessary for DNA synthesis in cells during chromosome replication and cell division. Most of them exist in bone marrow cells. As a cofactor, cobaltamine is necessary for biochemical reactions in two kinds of cells:
(1) The mitochondrial methylmalonyl coenzyme A methylate mutase converts methylmalonic acid (MMA) into succinate, which is related to the metabolism of lipids and carbohydrates;
(2) Activation of methionine synthetase, which is the rate-limiting step of methionine synthesis from homocysteine and 5-methyltetrahydrofolate.
Hydroxycobalamin is an intermediate for the synthesis of nitrocobalamin and a useful intermediate for the synthesis of cobalamin acetate; Physiological analogue of vitamin B12, in which the CN group is replaced by OH. It exists in aqueous solution as an equilibrium mixture of hydroxyl isomer and ionic water isomer (aquacobalamin). Coenzyme methylcobalamin and precursor of cobalamin. Coordination compounds. Vitamins (hematopoiesis).
It can be used for pernicious anemia and other diseases caused by vitamin B12 deficiency. It can be used in large doses as an antidote for cyanide to convert cyanide into cyanocobalamine.
