Ligustrum Extract
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Ligustrum Extract

Product Name:Ligustrum extract
Alias: Fructus Ligustri extract
Appearance:Brown yellow powder
Usage: Medical and health products, beverage and food additives, etc.

Ligustrum lucidum extract introduction

Ligustrum lucidum seed extract is the fruit extract of Ligustrum lucidum, which mainly contains oleanolic acid, polysaccharide, fatty oil and other components of organic acids. It has the effect of nourishing liver and kidney, brightening eyes and blackening hair. It is used for dizziness, tinnitus, aching waist and knees, early white hair, and unclear eyes.

Ligustrum lucidum seed extract Source plants

Ligustrum lucidum is an evergreen shrub or tree of the genus Ligustrum in the Oleaceae family, with a height of up to 25 meters; The bark is grayish brown. Branches yellowish brown, gray, or purplish red, cylindrical, sparsely rounded or oblong lenticels.

Ligustrum lucidum is a subtropical tree species with dense foliage and neat tree shape. It is commonly used as an ornamental tree species, and can be planted alone or in clusters in courtyards, roadside trees, hedges, etc. Ligustrum lucidum is native to China and widely distributed in the Yangtze River basin and southern regions. It is also cultivated in North and Northwest China and can withstand low temperatures of around - 10 ℃. It is a native tree species widely used in landscaping. It is mainly distributed in Jiangsu, Zhejiang, Jiangxi, Anhui, Shandong, Sichuan, Guizhou, Hubei, Guangdong, Fujian, and other places. Adopt sowing, cutting, and layering methods for propagation. Leaves can be distilled to extract holly oil, which is used as an additive in desserts and toothpaste. The mature fruit is dried in the sun to become the traditional Chinese medicine Ligustrum lucidum. It has a cool nature, a sweet and bitter taste, can brighten the eyes, blacken hair, and tonify the liver and kidney.

Ligustrum lucidum fruit extract pharmacological action

1. Enhance immune function

The extract of Ligustrum lucidum (1 ∶ 1000) can increase the percentage of EaRFC (Ea rosette recovery) of human lymphocytes, and promote the response of T cells to low-dose phytohemagglutinin (PHA). In vitro, the aqueous extract of Ligustrum lucidum could significantly enhance the lymphocyte proliferation induced by PHA, concanavalin (ConA) and Phytolacca americana mitogen (PWM).

2. Effect on cardiovascular system

100% ligustrum lucidum water decoction alcohol solution can increase the coronary flow of isolated rabbit heart, but at the same time, it can inhibit the myocardial contractility, and has no obvious effect on heart rate. The total ethyl acetate extract of ligustrum lucidum leaf, 50 mg/kg, injected intravenously in rabbits, has a protective effect on acute myocardial ischemia caused by pituitrin (2U/kg), and can improve the electrocardiogram of myocardial ischemia.

3. Increase white blood cells

Fructus Ligustri lucidi has an increasing effect on the leukopenia caused by chemotherapy or radiotherapy. In mice, the alcohol extract of Fructus Ligustri lucidi 40 g/(kg · d) can significantly resist the leukopenia caused by cyclophosphamide.

4. Hypoglycemic

Oleanolic acid significantly reduced the blood glucose of normal mice, with the dosage of 50 mg/(kg · d) and 100 mg/(kg · d). The blood glucose values were (71.2 ± 9.5) and (52.7 ± 13.7) mg/dL respectively after 4 days of oral administration, and (109.8 ± 10.5) mg/dL in the control group. There are very significant differences.

5. Antibacterial effect

50% Ligustrum lucidum decoction can inhibit Staphylococcus aureus, Shigella flexneri, Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli.

6. Anticancer effect

The water extract of Ligustrum lucidum Ait 60g/kg by gavage, one dose per day, showed an inhibitory rate of 49.2% on mouse cervical cancer 14 (Ⅴ - 14), but it was ineffective on sarcoma S180 and lymphoma (L1) ascites. Ligustrum lucidum extract can inhibit the growth of some transplanted tumors in animals. Oleanolic acid can reduce SGPT and protect liver; Mannitol can reduce intracranial pressure, intraocular pressure and diuretic effect.

7. Anti-liver damage effect

The subcutaneous injection of oleanolic acid can inhibit the increase of serum glutamic pyruvic transaminase in rats caused by carbon tetrachloride, and can also reduce glutamic pyruvic transaminase in rats not treated with carbon tetrachloride. It can also reduce the liver damage caused by carbon tetrachloride.

8. Anti inflammatory effect

It has obvious inhibitory effect on xylene induced auricle swelling in mice, acetic acid induced increase of capillary permeability in mice's abdominal cavity, and carrageenan, egg white and formaldehyde induced foot pad swelling in rats.

9. Other roles

The extract of Ligustrum lucidum also has the effects of anti-aging, anti fatigue, lipid lowering and enzyme lowering.