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Pterostilbene is an active ingredient derived from plants such as rosewood, blueberry, grape and flower palm. Pterostilbene has anti-cancer, anti-inflammatory, antioxidant and analgesic properties. A large number of studies have shown that pterostilbene has a good effect in the treatment and protection of skin diseases, especially in the fields of anti-oxidation.
As the antifungal active ingredient in the dragon's blood products, red sandalwood stilbene belongs to the polyhydroxystilbene compound, and is the homologue of resveratrol. Its pharmacological action is not only partially similar to resveratrol, but also has strong antifungal activity (its antifungal activity is five times that of resveratrol).
Pterostilbene is a white or off-white crystalline powder, sensitive to air, with a melting point of 89-92°C. Store at 2-8°C sealed and protected from light.
As an antioxidant, pterostilbene can resist cell proliferation, lower blood lipids, inhibit COX-1 and COX-2, fight cancer and fight fungi.
1. Colon cancer
Colon cancer is one of the common malignant tumors, with the highest incidence in the 40-50 age group. According to the world epidemiological survey, it is found that colon cancer has the highest incidence rate in North America, Western Europe, Australia, New Zealand and other places, and ranks second in visceral tumors. The incidence rate and mortality rate in my country are increasing year by year.
After years of experiments on animals, American scientists found that this compound extracted from blueberries and grapes can inhibit an enzyme called "P450 cytochrome", which can activate chemical carcinogens, and can reduce low-density lipoprotein cholesterol, so it has the function of preventing cancer and heart disease. Pterostilbene is an aromatic hydrocarbon called "styrene" which is a derivative of resveratrol. In the early 1990s, American scientists discovered that resveratrol has the function of preventing breast cancer and heart disease, and it exists in large quantities in red grape skins.
Pterostilbene helps stop precancerous damage to the body. Acts as an antioxidant and anti-inflammatory, found in both blueberries and blackberries. The Ohio State University in the United States found that animals that ate rough berries had an 80% lower chance of developing colon cancer, and a 60% lower chance of suffering from digestive tract tumors; German investigators found that drinking 2-3 cups of juice a day can also treat colon cancer.
According to statistics, after 8 weeks of continuous consumption of blueberries or grapes containing pterostilbene, the precancerous lesions in the colon were reduced by 57%. Reduced the spread of bowel cancer cells and was able to suppress certain genes that trigger inflammation, both of which are considered risk factors for colon cancer.
2. Associated with skin tumors
Skin tumors are among the most common human tumors in the range. Epidemiological data show that UV radiation is the main carcinogen in skin tumors. UV irradiation stimulates the proliferation of abnormal skin cell clones, leading to cell canceration through multiple signal transduction pathways. Many plant compounds, such as resveratrol and grape seed extract, have inhibitory effects on chemically induced skin tumors in mice. Regulate the survival of intermediate cell biomarkers by inhibiting epidermal hyperplasia and cell proliferation; Reduce inflammation marker COX-2, oncogene mutation and cell apoptosis to inhibit the occurrence of skin tumors. Resveratrol can reduce the skin papilloma induced by dimethylbenzanthracene/croton oil in mice by 60%, reduce the incidence rate of papilloma by prolonging the latency of tumor occurrence, and reduce the number of tumors in each mouse in a dose-dependent manner. Astragalus roseus can inhibit the growth of cancer cells, induce cell apoptosis, and inhibit tumor growth and metastasis in vivo by changing cell cycle. In addition, red sandalwood and resveratrol can significantly activate Nrf2 to enhance the expression of antioxidant enzymes, such as heme oxygenase-1 and glutathione reductase. Pterostilbene can also induce tumor cell death through lysosomal membrane permeability. Melanoma is a skin tumor with a high degree of malignancy due to its strong erosiveness, early metastasis and high mortality. Astragalus roseus and quercetin inhibit the growth and metastasis of metastatic melanoma. The mechanism is to inhibit the expression of adhesion molecule-1 in rat hepatic sinusoid endothelial cells, thereby reducing the adhesion of B16M-F10 cells to endothelial cells, while inhibiting the expression of metastatic cell Bcl-2, reducing the cytotoxicity of vascular endothelial cells. At the same time, red sandalwood root significantly inhibited NF- κ B and activator protein 1 activate induced skin tumors.
3. Anti-inflammatory
Pterostilbene may activate reduced coenzyme II oxidase through protein kinase C, thereby stimulating neutrophils not to produce superoxide superoxide anion and myeloperoxidase, its effect decreased significantly at 100 μmol/L, so the effect of pterostilbene may be dose-dependent. Red sandalwood root has inhibitory effect on nuclear factor NF- κ B activation, thus inhibiting the activation of pro-inflammatory cytokines and nitric oxide synthase genes, leading to tumor necrosis factor α、 Interleukin 1 β、 The secretion of interleukin 6 and nitric oxide is reduced, thus reducing the inflammatory stimulation.
Pterostilbene is an active ingredient derived from plants such as rosewood, blueberry, grape and flower palm. Pterostilbene has anti-cancer, anti-inflammatory, antioxidant and analgesic properties. A large number of studies have shown that pterostilbene has a good effect in the treatment and protection of skin diseases, especially in the fields of anti-oxidation.
As the antifungal active ingredient in the dragon's blood products, red sandalwood stilbene belongs to the polyhydroxystilbene compound, and is the homologue of resveratrol. Its pharmacological action is not only partially similar to resveratrol, but also has strong antifungal activity (its antifungal activity is five times that of resveratrol).
Pterostilbene is a white or off-white crystalline powder, sensitive to air, with a melting point of 89-92°C. Store at 2-8°C sealed and protected from light.
As an antioxidant, pterostilbene can resist cell proliferation, lower blood lipids, inhibit COX-1 and COX-2, fight cancer and fight fungi.
1. Colon cancer
Colon cancer is one of the common malignant tumors, with the highest incidence in the 40-50 age group. According to the world epidemiological survey, it is found that colon cancer has the highest incidence rate in North America, Western Europe, Australia, New Zealand and other places, and ranks second in visceral tumors. The incidence rate and mortality rate in my country are increasing year by year.
After years of experiments on animals, American scientists found that this compound extracted from blueberries and grapes can inhibit an enzyme called "P450 cytochrome", which can activate chemical carcinogens, and can reduce low-density lipoprotein cholesterol, so it has the function of preventing cancer and heart disease. Pterostilbene is an aromatic hydrocarbon called "styrene" which is a derivative of resveratrol. In the early 1990s, American scientists discovered that resveratrol has the function of preventing breast cancer and heart disease, and it exists in large quantities in red grape skins.
Pterostilbene helps stop precancerous damage to the body. Acts as an antioxidant and anti-inflammatory, found in both blueberries and blackberries. The Ohio State University in the United States found that animals that ate rough berries had an 80% lower chance of developing colon cancer, and a 60% lower chance of suffering from digestive tract tumors; German investigators found that drinking 2-3 cups of juice a day can also treat colon cancer.
According to statistics, after 8 weeks of continuous consumption of blueberries or grapes containing pterostilbene, the precancerous lesions in the colon were reduced by 57%. Reduced the spread of bowel cancer cells and was able to suppress certain genes that trigger inflammation, both of which are considered risk factors for colon cancer.
2. Associated with skin tumors
Skin tumors are among the most common human tumors in the range. Epidemiological data show that UV radiation is the main carcinogen in skin tumors. UV irradiation stimulates the proliferation of abnormal skin cell clones, leading to cell canceration through multiple signal transduction pathways. Many plant compounds, such as resveratrol and grape seed extract, have inhibitory effects on chemically induced skin tumors in mice. Regulate the survival of intermediate cell biomarkers by inhibiting epidermal hyperplasia and cell proliferation; Reduce inflammation marker COX-2, oncogene mutation and cell apoptosis to inhibit the occurrence of skin tumors. Resveratrol can reduce the skin papilloma induced by dimethylbenzanthracene/croton oil in mice by 60%, reduce the incidence rate of papilloma by prolonging the latency of tumor occurrence, and reduce the number of tumors in each mouse in a dose-dependent manner. Astragalus roseus can inhibit the growth of cancer cells, induce cell apoptosis, and inhibit tumor growth and metastasis in vivo by changing cell cycle. In addition, red sandalwood and resveratrol can significantly activate Nrf2 to enhance the expression of antioxidant enzymes, such as heme oxygenase-1 and glutathione reductase. Pterostilbene can also induce tumor cell death through lysosomal membrane permeability. Melanoma is a skin tumor with a high degree of malignancy due to its strong erosiveness, early metastasis and high mortality. Astragalus roseus and quercetin inhibit the growth and metastasis of metastatic melanoma. The mechanism is to inhibit the expression of adhesion molecule-1 in rat hepatic sinusoid endothelial cells, thereby reducing the adhesion of B16M-F10 cells to endothelial cells, while inhibiting the expression of metastatic cell Bcl-2, reducing the cytotoxicity of vascular endothelial cells. At the same time, red sandalwood root significantly inhibited NF- κ B and activator protein 1 activate induced skin tumors.
3. Anti-inflammatory
Pterostilbene may activate reduced coenzyme II oxidase through protein kinase C, thereby stimulating neutrophils not to produce superoxide superoxide anion and myeloperoxidase, its effect decreased significantly at 100 μmol/L, so the effect of pterostilbene may be dose-dependent. Red sandalwood root has inhibitory effect on nuclear factor NF- κ B activation, thus inhibiting the activation of pro-inflammatory cytokines and nitric oxide synthase genes, leading to tumor necrosis factor α、 Interleukin 1 β、 The secretion of interleukin 6 and nitric oxide is reduced, thus reducing the inflammatory stimulation.
