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The brownish yellow powdery substance extracted from the dried root tubers of ophiopogon japonicus, a lily plant, mainly contains active ingredients such as polysaccharides, saponins, flavonoids, etc. It has certain effects of anti myocardial ischemia, anti arrhythmia, antiasthmatic, cardiac strengthening, hypoglycemic, immune enhancement, anti hypersensitivity, anti radiation, anti-aging, etc.
Ophiopogon japonicus is native to China, and is cultivated in southern China and other places. It is also distributed in Japan, Vietnam, and India. Born in shady and humid hillsides, under forests, or beside streams below an altitude of 2000 meters.
The small root of Ophiopogon japonicus is a traditional Chinese medicine with the effects of promoting fluid production, relieving thirst, moistening the lungs, and relieving cough. It is widely cultivated and has a long history.
1. Impact on central nervous system
The intraperitoneal injection of total amino acids of ophiopogon japonicus has obvious synergistic inhibitory effect on the central nervous system of mice with pentobarbital sodium, while total saponins and total sugars of ophiopogon japonicus have no obvious effect on the subthreshold hypnotic dose of pentobarbital sodium. 15% ophiopogon japonicus preparation can inhibit the fever of rabbits caused by turpentine, but the drug has no inhibitory effect after the fever. The decoction has a sedative effect, can also enhance the sedative effect of chlorpromazine, enhance the hypnotic effect of pentobarbital sodium, antagonize the excitatory effect of caffeine, and can delay the time of convulsion, tetanic convulsion and death caused by Huisuling, but it can not prevent animals from death.
2. Impact on cardiovascular system
The total saponins of ophiopogon japonicus can enhance the myocardial contractility of isolated toad heart, which is less effective than the crude extract. High dose of total saponins and total sugars can inhibit the heart, weaken the contractility, reduce the output, block the atrioventricular conduction and even stop the beating. Small doses of total saponins and total amino acids of ophiopogon japonicus could enhance the contractility of isolated guinea pig hearts and increase the coronary flow, while large doses could inhibit the myocardium and reduce the coronary flow, but had no effect on heart rate. The total saponins of ophiopogon japonicus can effectively prevent or resist the arrhythmias induced by CHCl3 Adr, BaCl2 and Aco, and reduce the incidence of ventricular arrhythmias after coronary ligation in dogs. The total saponins of ophiopogon japonicus can significantly reduce the Vmax of single action potential in rabbits, and shorten their APD10 and APD50; APA and Vmax of transmembrane potential of guinea pig papillary muscle cells were significantly reduced, APD10 and APD50 were significantly shortened, and ERP/APD was significantly increased. Ophiopogon japonicus can improve the arrhythmias caused by barium chloride, aconitine, adrenaline and pituitrin. Ophiopogon japonicus combined with low-dose magnesium sulfate has a certain preventive effect on arrhythmias after experimental myocardial infarction in dogs. Ophiopogon japonicus can reduce the release of cAMP and cGMP in myocardium after experimental myocardial infarction in rabbits, and restore the balance of cAMP/cGMP ratio in plasma.
3. Impact on immune function
Ophiopogon japonicus polysaccharides and Ophiopogon japonicus decoction can significantly increase the weight of spleen in mice, but have no significant effect on the weight of thymus, and can significantly enhance the clearance rate of carbon particles in mice. Ophiopogon japonicus polysaccharide can obviously promote the formation of serum hemolysin in mice, and has lectin like effect on rabbit red blood cells. Ophiopogon japonicus L. can promote the production of SRBC antibody in young mice, delay the regression of antibody, and improve the cellular immunity of mice. The aqueous solution of ophiopogon japonicus whisker can significantly improve the white blood cells and T cells of mice inoculated with S180 and EAC cancer cells, and can increase the content of Tu%, decrease the content of Tr%, and increase the ratio of Tu/Tr.
4. Free radical scavenging effect
The scavenging rate of ophiopogon japonicus fibrous root ointment on oxygen free radicals reached 96.5%, the scavenging rate of OH - produced by Fenton reaction reached 98.4%, and the scavenging rate of living oxygen free radicals produced by PMA stimulated human polymorphonuclear leukocyte respiratory burst reached 85.3%.
5. Effect on blood sugar
Rabbits injected with 50% ophiopogon japonicus decoction intramuscularly (1mL/kg) can increase blood sugar. The water and alcohol extracts of Ophiopogon japonicus L. by gavage 0.2g/kg had hypoglycemic effect in normal rabbits; For alloxan induced diabetes rabbits, 0.5 g/kg/day for 4 consecutive days also had hypoglycemic effect, and promoted the recovery of pancreatic islet cells. The hepatic glycogen increased compared with the control group. Ophiopogon japonicus polysaccharide can reduce the blood sugar concentration of normal mice and alloxan diabetes mice, and the hypoglycemic effect does not increase with the increase of dosage.
6. Antibacterial effect
Ophiopogon japonicus extract has antibacterial effect on Staphylococcus albus, Escherichia coli, Bacillus subtilis and typhoid bacillus in vitro.
7. Anti tumor effect
Ophiopogon japonicus polysaccharide can inhibit the growth of S180 sarcoma and ascites tumor, and also has a certain inhibitory effect on the solid tumor of primary liver cancer in mice. At the same time, the classic prescription Maimendong Decoction can also play a very good role in the treatment of advanced tumors.
8. Effect on gastrointestinal tract
Ophiopogon japonicus polysaccharide has a certain therapeutic effect on atrophic gastritis, which is mainly related to improving the blood circulation of gastric mucosa, inhibiting inflammatory reaction, and promoting the proliferation of tissue cells.
9. Other functions
Ophiopogon japonicus polysaccharide can significantly prolong the time of normal pressure hypoxia tolerance in mice, and significantly resist the decline of white blood cells in mice caused by 60Co radiation. Ophiopogon japonicus polysaccharides and Ophiopogon japonicus decoction can significantly resist the decrease of white blood cells in mice caused by cyclophosphamide. Feeding Ophiopogon japonicus root whiskers can reduce the hydroxyproline content in mice, inhibit the activity of monoamine oxidase in the brain of male mice, increase the activity of SOD in the liver of male mice, and significantly prolong the life span of drosophila melanogaster. Saponins, polysaccharides and amino acids contained in ophiopogon japonicus have obvious anti fatigue effect on mice. Ophiopogon japonicus can promote the growth of granulocyte in mice.
The brownish yellow powdery substance extracted from the dried root tubers of ophiopogon japonicus, a lily plant, mainly contains active ingredients such as polysaccharides, saponins, flavonoids, etc. It has certain effects of anti myocardial ischemia, anti arrhythmia, antiasthmatic, cardiac strengthening, hypoglycemic, immune enhancement, anti hypersensitivity, anti radiation, anti-aging, etc.
Ophiopogon japonicus is native to China, and is cultivated in southern China and other places. It is also distributed in Japan, Vietnam, and India. Born in shady and humid hillsides, under forests, or beside streams below an altitude of 2000 meters.
The small root of Ophiopogon japonicus is a traditional Chinese medicine with the effects of promoting fluid production, relieving thirst, moistening the lungs, and relieving cough. It is widely cultivated and has a long history.
1. Impact on central nervous system
The intraperitoneal injection of total amino acids of ophiopogon japonicus has obvious synergistic inhibitory effect on the central nervous system of mice with pentobarbital sodium, while total saponins and total sugars of ophiopogon japonicus have no obvious effect on the subthreshold hypnotic dose of pentobarbital sodium. 15% ophiopogon japonicus preparation can inhibit the fever of rabbits caused by turpentine, but the drug has no inhibitory effect after the fever. The decoction has a sedative effect, can also enhance the sedative effect of chlorpromazine, enhance the hypnotic effect of pentobarbital sodium, antagonize the excitatory effect of caffeine, and can delay the time of convulsion, tetanic convulsion and death caused by Huisuling, but it can not prevent animals from death.
2. Impact on cardiovascular system
The total saponins of ophiopogon japonicus can enhance the myocardial contractility of isolated toad heart, which is less effective than the crude extract. High dose of total saponins and total sugars can inhibit the heart, weaken the contractility, reduce the output, block the atrioventricular conduction and even stop the beating. Small doses of total saponins and total amino acids of ophiopogon japonicus could enhance the contractility of isolated guinea pig hearts and increase the coronary flow, while large doses could inhibit the myocardium and reduce the coronary flow, but had no effect on heart rate. The total saponins of ophiopogon japonicus can effectively prevent or resist the arrhythmias induced by CHCl3 Adr, BaCl2 and Aco, and reduce the incidence of ventricular arrhythmias after coronary ligation in dogs. The total saponins of ophiopogon japonicus can significantly reduce the Vmax of single action potential in rabbits, and shorten their APD10 and APD50; APA and Vmax of transmembrane potential of guinea pig papillary muscle cells were significantly reduced, APD10 and APD50 were significantly shortened, and ERP/APD was significantly increased. Ophiopogon japonicus can improve the arrhythmias caused by barium chloride, aconitine, adrenaline and pituitrin. Ophiopogon japonicus combined with low-dose magnesium sulfate has a certain preventive effect on arrhythmias after experimental myocardial infarction in dogs. Ophiopogon japonicus can reduce the release of cAMP and cGMP in myocardium after experimental myocardial infarction in rabbits, and restore the balance of cAMP/cGMP ratio in plasma.
3. Impact on immune function
Ophiopogon japonicus polysaccharides and Ophiopogon japonicus decoction can significantly increase the weight of spleen in mice, but have no significant effect on the weight of thymus, and can significantly enhance the clearance rate of carbon particles in mice. Ophiopogon japonicus polysaccharide can obviously promote the formation of serum hemolysin in mice, and has lectin like effect on rabbit red blood cells. Ophiopogon japonicus L. can promote the production of SRBC antibody in young mice, delay the regression of antibody, and improve the cellular immunity of mice. The aqueous solution of ophiopogon japonicus whisker can significantly improve the white blood cells and T cells of mice inoculated with S180 and EAC cancer cells, and can increase the content of Tu%, decrease the content of Tr%, and increase the ratio of Tu/Tr.
4. Free radical scavenging effect
The scavenging rate of ophiopogon japonicus fibrous root ointment on oxygen free radicals reached 96.5%, the scavenging rate of OH - produced by Fenton reaction reached 98.4%, and the scavenging rate of living oxygen free radicals produced by PMA stimulated human polymorphonuclear leukocyte respiratory burst reached 85.3%.
5. Effect on blood sugar
Rabbits injected with 50% ophiopogon japonicus decoction intramuscularly (1mL/kg) can increase blood sugar. The water and alcohol extracts of Ophiopogon japonicus L. by gavage 0.2g/kg had hypoglycemic effect in normal rabbits; For alloxan induced diabetes rabbits, 0.5 g/kg/day for 4 consecutive days also had hypoglycemic effect, and promoted the recovery of pancreatic islet cells. The hepatic glycogen increased compared with the control group. Ophiopogon japonicus polysaccharide can reduce the blood sugar concentration of normal mice and alloxan diabetes mice, and the hypoglycemic effect does not increase with the increase of dosage.
6. Antibacterial effect
Ophiopogon japonicus extract has antibacterial effect on Staphylococcus albus, Escherichia coli, Bacillus subtilis and typhoid bacillus in vitro.
7. Anti tumor effect
Ophiopogon japonicus polysaccharide can inhibit the growth of S180 sarcoma and ascites tumor, and also has a certain inhibitory effect on the solid tumor of primary liver cancer in mice. At the same time, the classic prescription Maimendong Decoction can also play a very good role in the treatment of advanced tumors.
8. Effect on gastrointestinal tract
Ophiopogon japonicus polysaccharide has a certain therapeutic effect on atrophic gastritis, which is mainly related to improving the blood circulation of gastric mucosa, inhibiting inflammatory reaction, and promoting the proliferation of tissue cells.
9. Other functions
Ophiopogon japonicus polysaccharide can significantly prolong the time of normal pressure hypoxia tolerance in mice, and significantly resist the decline of white blood cells in mice caused by 60Co radiation. Ophiopogon japonicus polysaccharides and Ophiopogon japonicus decoction can significantly resist the decrease of white blood cells in mice caused by cyclophosphamide. Feeding Ophiopogon japonicus root whiskers can reduce the hydroxyproline content in mice, inhibit the activity of monoamine oxidase in the brain of male mice, increase the activity of SOD in the liver of male mice, and significantly prolong the life span of drosophila melanogaster. Saponins, polysaccharides and amino acids contained in ophiopogon japonicus have obvious anti fatigue effect on mice. Ophiopogon japonicus can promote the growth of granulocyte in mice.
