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Glaucoma is a slowly progressive degeneration of retinal ganglion cells and optic nerve axons that can lead to irreversible blindness if undiagnosed or untreated. Glaucoma is the second leading cause of blindness worldwide, accounting for 12.3% of all blindness. Modern studies have shown that pilocarpine hydrochloride has obvious effects of lowering intraocular pressure and controlling inflammation, and can treat primary glaucoma, including open-angle and angle-closure glaucoma, and is the first-line drug for clinical treatment of glaucoma. The commonly used dosage form of pilocarpine hydrochloride is eye drops, which has the disadvantages of short ocular residence time and poor corneal permeability.
M-type cholinergic drugs have a strong selective excitatory effect on gastrointestinal smooth muscle and various glands, but have little effect on the cardiovascular system and other organs. Promoting the secretion of salivary glands, lacrimal glands, and bronchial glands is the most obvious, but the effect on sweat glands is weaker. Eye drop or injection can produce miosis and reduce intraocular pressure. It is used to treat incompletely obstructed intestinal constipation, gastrointestinal relaxation, and can also be used as a miotic agent to treat iritis and glaucoma.
1. Primary glaucoma
2. Antagonize mydriasis
3. Accommodative esotropia
Glaucoma is a slowly progressive degeneration of retinal ganglion cells and optic nerve axons that can lead to irreversible blindness if undiagnosed or untreated. Glaucoma is the second leading cause of blindness worldwide, accounting for 12.3% of all blindness. Modern studies have shown that pilocarpine hydrochloride has obvious effects of lowering intraocular pressure and controlling inflammation, and can treat primary glaucoma, including open-angle and angle-closure glaucoma, and is the first-line drug for clinical treatment of glaucoma. The commonly used dosage form of pilocarpine hydrochloride is eye drops, which has the disadvantages of short ocular residence time and poor corneal permeability.
M-type cholinergic drugs have a strong selective excitatory effect on gastrointestinal smooth muscle and various glands, but have little effect on the cardiovascular system and other organs. Promoting the secretion of salivary glands, lacrimal glands, and bronchial glands is the most obvious, but the effect on sweat glands is weaker. Eye drop or injection can produce miosis and reduce intraocular pressure. It is used to treat incompletely obstructed intestinal constipation, gastrointestinal relaxation, and can also be used as a miotic agent to treat iritis and glaucoma.
1. Primary glaucoma
2. Antagonize mydriasis
3. Accommodative esotropia
