Pregelatinized Starch Medicinal Excipients
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Pregelatinized Starch Medicinal Excipients

Product Name:Pregelatinized starch (medicinal excipients)
CAS NO.:9005-25-8

Pregelatinized starch description

Pregelatinized starch is modified starch, which is obtained by chemically or mechanically breaking starch granules partially or completely. It is often used as a binder, diluent and disintegrant in tablets. Pregelatinized starch has self-lubricating effect. When used in combination with other excipients, magnesium stearate should be added as a lubricant. This product is non-toxic and non-irritating, but it is harmful when taken in large quantities.

Pregelatinized starch element

In general, pregelatinized starch contains 5% free amylose, 15% free amylopectin, and 80% unmodified starch. Molecular formula (C6H10O5) n, n=300~1000.

Pregelatinized starch preparation

Food-grade pregelatinized starch is prepared by heating 42% (w/w) aqueous starch slurry, and the temperature is controlled at 62-72°C. Gelling aids and surfactants need to be added to control rehydration or reduce viscosity during drying. After heating, water-based paste is formed, which is spray-dried, roller-dried, squeezed and dehydrated, or drum-dried, and finally pulverized to the desired particle size range.

The fully pregelatinized starch for medicinal purposes does not use additives, and the ungelatinized starch aqueous suspension is spread on the hot drum, and the gelatinization and drying processes are realized at the same time. Partially pregelatinized starch is prepared by mechanically pressurizing wet starch. The obtained semi-finished product is pulverized and the moisture content is adjusted to meet the standard.

Pregelatinized starch application

In the pharmaceutical field, it is used as a binder, diluent and disintegrant for oral capsules and preparations. Compared with starch, pregelatinized starch can increase flowability and compressibility, and it is used as a binder in dry tableting process, wherein pregelatinized starch acts as a self-lubricant.