Quick review of grape seed extract efficacy and precautions
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Quick review of grape seed extract efficacy and precautions

Views: 0     Author: Site Editor     Publish Time: 2022-07-15      Origin: Site

Grape seed extract mainly refers to OPCs (oligomeric proanthocyanidin complexes), which are natural plant metabolites widely present in fruits, vegetables, nuts, seeds and flowers. It is the most potent antioxidant of plant origin found so far. In vivo and in vitro tests have shown that the antioxidant effect of grape seed extract "Procyanidin OPC" is 50-70 times that of vitamin C and vitamin E.

Grape fruit seed extract effects

1. good blood pressure regulation

Hypertension is a chronic disease in which blood pressure increases. It significantly increases the risk of heart disease, stroke and renal insufficiency and is therefore the leading cause of death worldwide, with an overall prevalence of hypertension of around 40% in adults over 25 years of age.

Although high blood pressure is usually asymptomatic, people with severely elevated blood pressure may experience effects such as headache, dizziness, dizziness, or fainting. Grape seed extract can have a beneficial effect on blood pressure, especially in young or obese subjects and patients with metabolic diseases.

2. Beneficial for NAFLD

Nonalcoholic fatty liver disease is primarily defined by the accumulation of triglycerides in hepatocytes in excess of 5% of liver weight and occurs in the absence of alcohol.

It ranges from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis that can progress to cirrhosis and end-stage liver disease, and even hepatocellular carcinoma (HCC).

Common causative factors of fatty liver are obesity, type 2 diabetes, and metabolic syndrome, including dyslipidemia and hypertension.

In addition to improving liver function indicators: Aspartate Transaminase (AST), the use of grape seed extract also reduced the level of steatosis (measured by ultrasound) compared to the control group using vitamin C.black grape seed extract -Herbkey

3. Beneficial for Chronic Kidney Disease

Chronic kidney disease is a major health problem with an increasing prevalence worldwide, mainly defined as a glomerular filtration rate of less than 60 mL/min/1.73 m2 (with or without kidney damage) for 3 consecutive months, resulting in irreversibly lead to end-stage renal disease.

Regardless of the stage, possible complications of chronic kidney disease include drug toxicity, metabolic and endocrine disorders, anemia, bone loss, cardiovascular disease, as well as infections, frailty, and cognitive impairment. The main risk factors for developing chronic kidney disease are age, sex, race and ethnicity, family history, drug use, smoking, socioeconomic status, hypertension, and diabetes.

In addition to improving glomerular filtration rate (GFR) and proteinuria, oral administration of grape seed extract also helps to increase antioxidant status, improve inflammatory markers CRP, triglycerideemia, and fight against anemia and thrombocytopenia.

4. Improve menopausal disorders

Menopause is a period of changes in psychophysiological and social functions caused by decreased ovarian hormone activity and estrogen levels in women. About 85% of menopausal women have at least one menopausal symptom. Early menopausal symptoms include hot flashes, sweating, sleep disturbance, psychological changes, and menstrual disturbances, and later in menopause, urogenital atrophic changes and associated sexual dysfunction, cardiovascular disease, osteoporosis, and muscle and joint disorders may also occur .

Oral grape seed extract may help improve menopausal symptoms (including hot flashes, anxiety, and insomnia), increase muscle mass, and lower blood pressure (average 5 mm Hg).

5. Lessens the adverse effects of chemotherapy or radiation therapy

Chemotherapy is an essential part of many cancer treatments and is thought to reduce cancer recurrence and improve patient survival, and is one of the largest areas of drug development. However, the very nature of chemotherapy means that it damages healthy cells as well as cancer cells, leading to side effects. The most common side effects reported by patients during and after chemotherapy included nausea/vomiting, thrombocytopenia, mouth sores, and fatigue. Grape seed proanthocyanidins or grape seed extract can help reduce the toxic effects of chemotherapy or radiation therapy.

Red grape seed extract precautions

Grape seed extract is considered safe in moderate amounts, but possible side effects include: sore throat, headache, stomach pain, itchy scalp, dizziness, nausea.

Safety Precautions:

1. Do not use if you have ever been allergic to grape-related food. It may cause allergic reactions. Possible symptoms include: swelling of the face or hands, swelling or tingling in the mouth or throat, chest tightness, difficulty breathing, hives or rashes, if these occur symptoms, seek medical assistance immediately.

2. Pregnant women, nursing mothers, and those with poor liver and kidney function should not use it (due to unknown safety).

3. Grape seed extract may have anticoagulant or blood thinning effects, so it may increase the risk of bleeding if you are taking anticoagulants (warfarin, clopidogrel, aspirin), those with poor blood clotting function, or two weeks before surgery. .

4. Those who have been allergic to drugs or have any medical conditions should confirm with a doctor before use to ensure safety.

Can grape seed extract fight cancer?

There are quite a few experiments on the Internet about grape seed extract inhibiting cancer cells, but the conclusion will be marked with this sentence: in vitro experiments can inhibit cancer cells. Li Duo, a professor at the Department of Food Science and Nutrition at Zhejiang University, explained that the ability to inhibit cancer cells in vitro and the ability to inhibit cancer cells in vivo are two completely different things. The ability of in vitro experiments to inhibit cancer cells can only indicate that further research can be carried out on specific cancer cells. At present, there is no evidence that grape seed extract can inhibit cancer cells in vivo.