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Resveratrol, a non flavonoid polyphenol organic compound, is an antitoxin produced by many plants when stimulated. It can be synthesized in grape leaves and grape skins. It is a bioactive component in wine and grape juice. In vitro and animal experiments show that resveratrol has antioxidant, anti-inflammatory, anticancer and cardiovascular protective effects.
1. Anti aging. Resveratrol can prolong the life span of yeast, nematodes, fruit flies and lower fish.
2. Anti tumor and anti-cancer. Resveratrol has a significant inhibitory effect on a variety of tumor cells in mice, such as hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, leukemia and so on.
3. Prevention and treatment of cardiovascular diseases. Studies have shown that resveratrol can inhibit and reduce the occurrence and development of cardiovascular disease and reduce the risk of cardiovascular disease.
4. Resveratrol has antibacterial, antioxidant, immune regulation, anti asthma and other biological activities.
Resveratrol and its derivatives mainly exist in at least 72 species of plants in 21 families and 31 genera, including Vitis, Polygonum, Peanut, and Resveratrol, including Polygonum cuspidatum, Cassia, mulberry and other common medicinal plants, as well as grapes, peanuts and other crops. The main sources of natural resveratrol are Polygonum cuspidatum and Vitis.
Polygonum cuspidatum is a perennial shrubby herb belonging to the genus Polygonum in the family Polygonaceae. It is mainly distributed in provinces south of the Yangtze River and Hubei, Sichuan and other places in China. The root and rhizome of Polygonum cuspidatum are the main parts for extracting natural resveratrol. Natural resveratrol mainly exists in Polygonum cuspidatum in the form of polygonum cuspidatum glycoside, and the content of resveratrol in the plant is very small. The high content of resveratrol can be obtained through the method of biological fermentation. Among them, the content of resveratrol in the fresh root of Polygonum cuspidatum is higher than that in the fresh stem, and there is almost no resveratrol in the fresh leaves.
Grape is a deciduous vine belonging to the grape family, which is planted all over the north of the Yangtze River basin in China. The content of resveratrol in wild and cultivated grape in Hunan and Guizhou is relatively high. The content of resveratrol in grapes varies with varieties and different parts. Resveratrol in grapes mainly exists in vines, pericarp and seeds, and there is little or no resveratrol in pulp.
Resveratrol is a non-flavonoid polyphenol compound beneficial to human health. Resveratrol extracted from natural plants cannot meet people's demand for it. Therefore, scientific researchers have been committed to developing fast and safe chemical and biological synthesis methods to obtain resveratrol.
1. Solvent extraction method
Solvent extraction is one of the most widely used extraction methods at home and abroad. The commonly used solvent extraction methods mainly include three methods: percolation, extraction and reflux. The common solvents for reflux extraction of resveratrol include methanol, ethanol, acetone, ethyl acetate, etc. Among them, 60% - 90% ethanol aqueous solution is the most commonly used for reflux extraction of resveratrol original plants. Other solvents are rarely used because of their low efficiency or relatively high toxicity.
2. Enzymatic extraction
Resveratrol exists in many plants in the form of resveratrol glycoside. Resveratrol glycoside can be enzymatically hydrolyzed into resveratrol, and then free resveratrol can be extracted. This method can achieve higher yield, so some researchers have adopted enzymatic hydrolysis method to extract resveratrol. There are three kinds of enzyme sources in enzymatic extraction: using plant autoenzyme, adding external enzyme and producing enzyme by inoculating microorganism.
3. Microwave extraction
Microwave extraction is a method of extracting effective components from plants because the temperature of plant cells increases rapidly after absorbing microwave energy in the microwave field, and then expands and breaks. This method is commonly used in laboratory research.
4. Supercritical carbon dioxide extraction
Supercritical CO2 extraction is a process of extracting or separating some components in the mixture using CO2 fluid in supercritical state as solvent. Supercritical CO2 is characterized by stable nature, non-toxic, non-polluting environment, strong permeability and solubility, and good transmission and mobility.
Resveratrol, a non flavonoid polyphenol organic compound, is an antitoxin produced by many plants when stimulated. It can be synthesized in grape leaves and grape skins. It is a bioactive component in wine and grape juice. In vitro and animal experiments show that resveratrol has antioxidant, anti-inflammatory, anticancer and cardiovascular protective effects.
1. Anti aging. Resveratrol can prolong the life span of yeast, nematodes, fruit flies and lower fish.
2. Anti tumor and anti-cancer. Resveratrol has a significant inhibitory effect on a variety of tumor cells in mice, such as hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, leukemia and so on.
3. Prevention and treatment of cardiovascular diseases. Studies have shown that resveratrol can inhibit and reduce the occurrence and development of cardiovascular disease and reduce the risk of cardiovascular disease.
4. Resveratrol has antibacterial, antioxidant, immune regulation, anti asthma and other biological activities.
Resveratrol and its derivatives mainly exist in at least 72 species of plants in 21 families and 31 genera, including Vitis, Polygonum, Peanut, and Resveratrol, including Polygonum cuspidatum, Cassia, mulberry and other common medicinal plants, as well as grapes, peanuts and other crops. The main sources of natural resveratrol are Polygonum cuspidatum and Vitis.
Polygonum cuspidatum is a perennial shrubby herb belonging to the genus Polygonum in the family Polygonaceae. It is mainly distributed in provinces south of the Yangtze River and Hubei, Sichuan and other places in China. The root and rhizome of Polygonum cuspidatum are the main parts for extracting natural resveratrol. Natural resveratrol mainly exists in Polygonum cuspidatum in the form of polygonum cuspidatum glycoside, and the content of resveratrol in the plant is very small. The high content of resveratrol can be obtained through the method of biological fermentation. Among them, the content of resveratrol in the fresh root of Polygonum cuspidatum is higher than that in the fresh stem, and there is almost no resveratrol in the fresh leaves.
Grape is a deciduous vine belonging to the grape family, which is planted all over the north of the Yangtze River basin in China. The content of resveratrol in wild and cultivated grape in Hunan and Guizhou is relatively high. The content of resveratrol in grapes varies with varieties and different parts. Resveratrol in grapes mainly exists in vines, pericarp and seeds, and there is little or no resveratrol in pulp.
Resveratrol is a non-flavonoid polyphenol compound beneficial to human health. Resveratrol extracted from natural plants cannot meet people's demand for it. Therefore, scientific researchers have been committed to developing fast and safe chemical and biological synthesis methods to obtain resveratrol.
1. Solvent extraction method
Solvent extraction is one of the most widely used extraction methods at home and abroad. The commonly used solvent extraction methods mainly include three methods: percolation, extraction and reflux. The common solvents for reflux extraction of resveratrol include methanol, ethanol, acetone, ethyl acetate, etc. Among them, 60% - 90% ethanol aqueous solution is the most commonly used for reflux extraction of resveratrol original plants. Other solvents are rarely used because of their low efficiency or relatively high toxicity.
2. Enzymatic extraction
Resveratrol exists in many plants in the form of resveratrol glycoside. Resveratrol glycoside can be enzymatically hydrolyzed into resveratrol, and then free resveratrol can be extracted. This method can achieve higher yield, so some researchers have adopted enzymatic hydrolysis method to extract resveratrol. There are three kinds of enzyme sources in enzymatic extraction: using plant autoenzyme, adding external enzyme and producing enzyme by inoculating microorganism.
3. Microwave extraction
Microwave extraction is a method of extracting effective components from plants because the temperature of plant cells increases rapidly after absorbing microwave energy in the microwave field, and then expands and breaks. This method is commonly used in laboratory research.
4. Supercritical carbon dioxide extraction
Supercritical CO2 extraction is a process of extracting or separating some components in the mixture using CO2 fluid in supercritical state as solvent. Supercritical CO2 is characterized by stable nature, non-toxic, non-polluting environment, strong permeability and solubility, and good transmission and mobility.
