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Resveratrol, a non flavonoid polyphenol organic compound, is an antitoxin produced by many plants when stimulated. It can be synthesized in grape leaves and grape skins. It is a bioactive component in wine and grape juice.
1. Resveratrol has anti aging effect.
2. Resveratrol has a significant inhibitory effect on a variety of tumor cells, such as hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, leukemia and so on.
3. Resveratrol has antibacterial, antioxidant, immune regulation, anti asthma and other biological activities.
The content of resveratrol in natural organisms is not high, which can be converted by various methods.
1. Acid-base hydrolysis
The conversion of resveratrol is mainly to convert resveratrol glycosides in plants into their aglycones, which are usually achieved by acid hydrolysis or alkali hydrolysis. However, the acid-base hydrolysis reaction is generally required to be carried out under high temperature and high pressure, and the required conditions are severe, and the equipment requirements are high, which will cause certain damage to the environment.
2. Biotransformation
The conditions of biotransformation of resveratrol are relatively mild and the operation is simple. Therefore, enzymatic hydrolysis and microbial fermentation are generally used to convert resveratrol at this stage. In recent years, there are many research reports on the enzymatic hydrolysis of Polygonum cuspidatum, such as resveratrol obtained by enzymatic hydrolysis of Polygonum cuspidatum with its own enzymes, cellulase, and β-glucosidase. The microbial fermentation method can also greatly improve the yield of resveratrol in Polygonum cuspidatum. Some scholars used rhizozyme bacteria to ferment the crude extract of polygonoside in liquid state and convert polygonoside into resveratrol, with the conversion rate of 95.8%.
3. Polymerization
Resveratrol can also be obtained through the transformation of polymers in grapes. The content of resveratrol in grapes is relatively small, but it contains a series of resveratrol derivatives generated by dehydrogenation polymerization of resveratrol as the basic unit in plants, such as heyneanol A, dimer ε- Viniferin and δ- Viniferin, trimer α- Viniferin, tetramer laevifenol, higher oligomer, etc. Some studies have shown that the derivatives of resveratrol have similar biological activities to resveratrol, and some of them are even stronger in activity, selectivity and stability than resveratrol. These polymers can be converted into resveratrol under certain conditions. For example, by adjusting temperature and ultraviolet irradiation, they can stimulate the massive accumulation of resveratrol in grapes.
Resveratrol, a non flavonoid polyphenol organic compound, is an antitoxin produced by many plants when stimulated. It can be synthesized in grape leaves and grape skins. It is a bioactive component in wine and grape juice.
1. Resveratrol has anti aging effect.
2. Resveratrol has a significant inhibitory effect on a variety of tumor cells, such as hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, leukemia and so on.
3. Resveratrol has antibacterial, antioxidant, immune regulation, anti asthma and other biological activities.
The content of resveratrol in natural organisms is not high, which can be converted by various methods.
1. Acid-base hydrolysis
The conversion of resveratrol is mainly to convert resveratrol glycosides in plants into their aglycones, which are usually achieved by acid hydrolysis or alkali hydrolysis. However, the acid-base hydrolysis reaction is generally required to be carried out under high temperature and high pressure, and the required conditions are severe, and the equipment requirements are high, which will cause certain damage to the environment.
2. Biotransformation
The conditions of biotransformation of resveratrol are relatively mild and the operation is simple. Therefore, enzymatic hydrolysis and microbial fermentation are generally used to convert resveratrol at this stage. In recent years, there are many research reports on the enzymatic hydrolysis of Polygonum cuspidatum, such as resveratrol obtained by enzymatic hydrolysis of Polygonum cuspidatum with its own enzymes, cellulase, and β-glucosidase. The microbial fermentation method can also greatly improve the yield of resveratrol in Polygonum cuspidatum. Some scholars used rhizozyme bacteria to ferment the crude extract of polygonoside in liquid state and convert polygonoside into resveratrol, with the conversion rate of 95.8%.
3. Polymerization
Resveratrol can also be obtained through the transformation of polymers in grapes. The content of resveratrol in grapes is relatively small, but it contains a series of resveratrol derivatives generated by dehydrogenation polymerization of resveratrol as the basic unit in plants, such as heyneanol A, dimer ε- Viniferin and δ- Viniferin, trimer α- Viniferin, tetramer laevifenol, higher oligomer, etc. Some studies have shown that the derivatives of resveratrol have similar biological activities to resveratrol, and some of them are even stronger in activity, selectivity and stability than resveratrol. These polymers can be converted into resveratrol under certain conditions. For example, by adjusting temperature and ultraviolet irradiation, they can stimulate the massive accumulation of resveratrol in grapes.
