Rosmarinic Acid Extract
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Rosmarinic Acid Extract

Product Name:Rosmarinic acid
CAS NO.:20283-92-5
Molecular formula:C18H16O8
Molecular weight:360.31
Storage condition:2-8°C

Rosmarinic acid Introduction

Rosmarinic acid is an organic compound, a water-soluble natural phenolic acid compound isolated from rosemary, a plant of the Labiatae family. Rosmarinic acid is widely distributed, and mainly exists in various plants of Labiatae, Boraginaceae, Cucurbitaceae, Tiliaceae, and Umbelliferae, especially in Labiatae and Boraginaceae.

Rosmarinic acid is a natural antioxidant with strong antioxidant activity that helps prevent cell damage caused by free radicals, thus reducing the risk of cancer and arteriosclerosis. Rosmarinic acid has strong anti-inflammatory activity, and rosmarinic acid also has antibacterial, antiviral, and antitumor activities. Rosmarinic acid has demonstrated its important application value in the fields of pharmacy, food, cosmetics and so on.

Rosmarinic acid Physical and chemical properties

Rosmarinic acid is a water-soluble substance, the source of low content rosemary is light yellow to brown powder, high content is white powder; it is easy to absorb moisture; it has a special herbal smell of rosemary; melting point: 171 ° C ~ 175 ° C Ferric chloride-potassium ferricyanide solution is blue-green.

Stability: Rosmarinic acid has good stability. Salt and sucrose have no effect on the stability of rosmarinic acid; pH and temperature have little effect on the stability of rosmarinic acid, the results show that rosmarinic acid is more suitable for storage and use under acidic and low temperature conditions; light has no effect on the stability of rosmarinic acid. The influence of marinic acid is greater, so it should be kept away from light as much as possible when using it; Ca2+ and Mg2+ have a greater impact on the stability of rosmarinic acid, and other metal ions have little effect on rosmarinic acid, so they should be avoided when using Contact with calcium and magnesium; low concentrations of sodium benzoate and potassium sorbate have little effect on the stability of rosmarinic acid, and should be added in an appropriate amount according to the hygienic standards for the use of food additives; ascorbic acid has a certain impact on rosmarinic acid , the effect of low concentration is small; the oxidant hydrogen peroxide has a great influence on rosmarinic acid; the reducing agent sodium metabisulfite has a small effect on rosmarinic acid.

Rosmarinic acid pharmacological effect

1. Antioxidant effect

Rosmarinic acid has a strong activity of scavenging free radicals and anti-oxidation in the body. Studies have shown that its mechanism of action is: rosmarinic acid competes with unsaturated fatty acids to combine with lipid peroxyl to terminate the chain reaction of lipid peroxidation and reduce the rate of lipid peroxidation, while rosmarinic acid is oxidized to Quinoid; marinic acid can inhibit the respiratory burst of neutrophils and inhibit the release of lysosomes by reducing the concentration of intracellular calcium ions; inhibit the oxidation of low-density lipoprotein regulated by endothelial cells. The antioxidation effect of rosmarinic acid is related to its structure, and studies have shown that the o-diphenolic hydroxyl group is the material basis for scavenging free radicals. Moreover, the conjugated double bond at C3 has a synergistic effect.

2. Antidepressant effect

Rosmarinic acid has antidepressant effects on animal models of depression. Experiments were carried out on cell proliferation in the hippocampal gyrus of mice, and immunohistochemical analysis was performed with bromodeoxyuridine antibody to explore its mechanism of action. It was found that the labeled proliferating cells increased in the rosmarinic acid treatment group, combined with the forced swimming of the depression animal model Experiments have shown that rosmarinic acid produces an antidepressant-like effect at least in part through the proliferation of hippocampal newborn cells.

3. Antibacterial effect of rosmarinic acid

Rosmarinic acid has broad-spectrum antimicrobial activity and has inhibitory effects on both bacteria and fungi. Rosmarinic acid has obvious inhibitory effect on bacteria such as Bacillus subtilis, Bacillus luteus, Escherichia coli, Staphylococcus aureus and Rhizococcus solani. It is scientifically found that rosmarinic acid can inhibit the growth and biofilm formation of Streptococcus dental caries and Streptococcus mutans, and reduce their glucosyltransferase activity, indicating that rosmarinic acid can be used for the prevention and treatment of oral diseases. Research on the antibacterial mechanism of rosmarinic acid shows that: on the one hand, rosmarinic acid can increase the permeability of bacterial cell membranes, causing a large amount of leakage of carbohydrates and proteins, affecting the normal metabolism of bacteria; on the other hand, it can also affect bacterial protein. Metabolism, also inhibits Taq DNA polymerase. Rosmarinic acid has antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus, but the sensitivity of Staphylococcus aureus to rosmarinic acid is significantly higher than that of Escherichia coli.

(1) Inhibition of bacteria: Rosmarinic acid has a significant inhibitory effect on Bacillus subtilis, Luteus luteus and Escherichia coli.

(2) Inhibition of fungi: Inhibitory activity of rosmarinic acid on hyphal growth and spore germination of different plant pathogenic fungi.

(3) Inhibition of mold: Rosmarinic acid extracted from plants can inhibit Phytophthora and its mold spores that cause soil-borne diseases, and effectively reduce the germination of zoospores.

4. Anti-inflammatory effects of rosmarinic acid

1) Anti-nephritis effect: Rosmarinic acid can inhibit the proliferation of glomerular mesangial cells and the expansion of glomeruli.

(2) Anti-hepatitis effect: Rosmarinic acid can reduce lipopolysaccharide (LPS)-induced liver damage and significantly inhibit the increase of plasma transaminase levels, which proves that the hepatoprotective effect of rosmarinic acid is through the removal or reduction of superoxide Or oxidized nitrite instead of inhibiting TNF-α.

(3) Anti-pneumonia effect: Rosmarinic acid inhibits neutrophil retention and interstitial edema induced by diesel exhaust particles in lung injury.

(4) Anti-arthritis effect: Rosmarinic acid can inhibit collagen-induced arthritis and significantly reduce the number of arthritis and affected joints.

(5) Anti-periodontitis effect: Rosmarinic acid can inhibit the formation of bacterial plaque, thereby preventing chronic gingivitis.

(6) Anti-dermatitis effect: Rosmarinic acid can relieve atopic dermatitis, also known as atopic eczema or atopic eczema.

5. Antiviral effect of rosmarinic acid

(1) Anti-herpes virus: Rosmarinic acid has special activity on type I and type II herpes simplex virus, and is an effective ingredient for controlling herpes disease. In addition to inhibiting certain enzyme activities in the virus life cycle, its antiviral activity , It can also quickly bind to the viral coat protein, thereby inactivating the virus.

(2) Anti-HIV: Rosmarinic acid can inhibit the activity of HIV-1 (human immunodeficiency virus 1) integrase.

(3) Anti-encephalitis virus: Rosmarinic acid can reduce the mortality of mice with Japanese encephalitis virus, significantly reduce the viral load, and make the virus less likely to spread.

6. Anticancer and antitumor effects of rosmarinic acid

Rosmarinic acid inhibits the expression of CCL11 and CCR3 by inhibiting the activity of β-kinase and the activation of related genes of nuclear factor kappa B, so as to achieve the purpose of anti-tumor.

7. Antiallergic effects of rosmarinic acid

Rosmarinic acid inhibits allergic inflammation induced by microallergens.

8. Antioxidant effect of rosmarinic acid

Rosmarinic acid has good free radical scavenging and antioxidant effects.

9. Antithrombotic and antiplatelet aggregation effects of rosmarinic acid

Rosmarinic acid can inhibit the formation of malondialdehyde in human platelets in vitro, and its IC50 value is 3.37nmol/L, showing that rosmarinic acid has anti-platelet aggregation activity.

10. Antidepressant effects of rosmarinic acid

11. Anti-radiation and anti-ultraviolet effect of rosmarinic acid

Rosmarinic acid can be used as a photoprotectant to protect against radiation and ultraviolet rays.

12. Other effects of rosmarinic acid

(1) Stabilizing effect on color

(2) Inhibitory effect on hyaluronidase

(3) Inhibitory effect on xanthine oxidase

(4) Liver protection

(5) Inhibition of angiogenesis

(6) Prevent arteriosclerosis

(7) Prevent memory damage

(8) Used as cosmetics