Silymarin
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Silymarin

Product Name: Silymarin
CAS NO.:65666-07-1
Molecular formula:C25H22O10
Molecular weight:482.44
Appearance:Yellow or brown powder
EINECS NO.: 613-830-9
Storage condition:-20°C
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Pure silymarin function

1. Eliminate active oxygen

It can directly remove active oxygen, resist lipid peroxidation, and maintain the fluidity of cell membrane.

2. Hepatoprotective effect

Silymarin has a protective effect on liver damage caused by carbon tetrachloride, galactosamine, alcohols and other liver toxins.

3. Antineoplastic effect

Various reactive oxygen species can oxidize guanine to form 8-orylguanine, causing DNA damage, and then causing tumors. The application of antioxidants, especially free radical scavengers, can prevent this process.

4. Anti cardiovascular effect

Ksoottva et al. studied the antioxidant effect of silymarin extract on high cholesterol and low-density lipoprotein in mice. They fed the mice with polyunsaturated fatty acids containing silymarin extract and a small amount of saturated fatty acids. Compared with the mice fed with polyunsaturated fatty acids and a small amount of saturated fatty acids, the cholesterol content in serum of the former was significantly reduced, VLDL hair was reduced, and HDL-C was increased, It shows that silymarin can improve the ability of anti LDL.

5. Protective effect on cerebral ischemic injury

Feng Quan et al. used the four vessel occlusion method to create a rat model of global cerebral ischemia to explore the mechanism of the protective effect of silymarin on cerebral ischemic injury. By observing the expression of silymarin on nitric oxide and nitric oxide synthase in brain homogenate, it showed that silymarin significantly reduced the infarct area while significantly reducing the content of NO and NOS in brain tissue of ischemic rats. Therefore, it is concluded that silymarin can improve the antioxidant capacity of the body and has a significant protective effect on cerebral ischemic injury.

Silymarin powder pharmacological action

It has been proved that in various pathological models of toxic liver damage, silymarin can neutralize α- Amanitin (toxic substance found in Guibi Amanita fungus), carbon tetrachloride, galactosamine, thioacetamide and liver virus FV3.

The curative effect of silymarin is attributed to its several action points and action mechanisms due to its ability to capture free radicals. Silymarin has antioxidant activity. The pathophysiological process of lipid peroxidation (causing damage to cell membrane) can be blocked or prevented by silymarin. In the damaged liver cells, silymarin stimulates protein synthesis and normalizes phospholipid metabolism.

In conclusion, the greatest contribution of silymarin is to stabilize the liver cell membrane, which prevents or avoids the loss of soluble cell components (such as transaminase). Silymarin may limit certain hepatotoxic substances (e.g α- Amanitin) penetrates into cells. The enhancement of protein synthesis ability is due to silymarin stimulating the activity of RNA polymerase I in the nucleus, thus helping the synthesis of ribosomal RNA in liver cells, and leading to a large number of structural and functional proteins (enzymes). Therefore, silymarin can enhance the repair ability and regeneration ability of liver cells.


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