Sodium Bicarbonate Medicinal Excipients
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Sodium Bicarbonate Medicinal Excipients

Product Name:Sodium bicarbonate (medicinal excipients)
CAS NO.:144-55-8
Molecular formula:NaHCO₃
Molecular weight:84.01
Appearance:White powder or opaque monoclinic fine crystal
Density: 2.20 g/cm³
EINECS NO.: 205-633-8
Storage condition:2-8°C
Water solubility: soluble in water, insoluble in ethanol
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Sodium bicarbonate description

Sodium bicarbonate is an inorganic compound, white crystalline powder, odorless, salty, soluble in water. It decomposes slowly in humid air or hot air to produce carbon dioxide, which is completely decomposed when heated to 270°C. In case of acid, it is strongly decomposed to produce carbon dioxide.

Sodium bicarbonate physical properties

Sodium bicarbonate is white crystal, or opaque monoclinic fine crystal, odorless, slightly salty taste and cool in nature, easily soluble in water and glycerol, insoluble in ethanol. The solubility in water is 7.8 g (18 ℃), 16.0 g (60 ℃), the density is 2.20 g/cm3, the specific gravity is 2.208, the refractive index is α: 1.465; β: 1.498; γ: 1.504, the standard entropy is 24.4 J/(mol ·K), heat of formation 229.3 kJ/mol, heat of dissolution 4.33 kJ/mol, specific heat capacity (Cp) 20.89 J/(mol °C) (22 °C).

Sodium bicarbonate application field

1. Laboratory use

Sodium bicarbonate can be used as an analytical reagent and also used in inorganic synthesis. It can be used to prepare sodium carbonate-sodium bicarbonate buffer solution. When adding a small amount of acid or alkali, it can keep the hydrogen ion concentration unchanged and keep the pH value of the system relatively stable.

2. Industrial use

Sodium bicarbonate can be used in the production of acid-base fire extinguishers and foam fire extinguishers. In the rubber industry, sodium bicarbonate can be used in the production of rubber and sponge. In the metallurgical industry, sodium bicarbonate can be used as a flux for casting steel ingots. In the machinery industry, sodium bicarbonate can be used as a molding aid for cast steel (turning) sand molds. In the printing and dyeing industry, sodium bicarbonate can be used as a fixing agent for dyeing and printing, an acid-base buffer, and a post-treatment agent for fabric dyeing and finishing; adding baking soda in dyeing can prevent the yarn from producing colored flowers, and it can also be used for wool washing agent.

1. Food processing use

In food processing, sodium bicarbonate is the most widely used loosening agent, which is used to produce biscuits, bread, etc., but sodium carbonate will remain after the action. Excessive use will cause excessive alkalinity of food, resulting in poor flavor and yellowish brown color. It is the generating agent of carbon dioxide in soft drinks; It can be compounded with alum to form alkaline fermentation powder, or with soda ash to form civil soda; It can also be used as a butter preservative. It can be used as a color fixative in vegetable processing. Adding 0.1%~0.2% sodium bicarbonate to wash fruits and vegetables can make the green color stable. When sodium bicarbonate is used as a treatment agent for fruits and vegetables, it can increase the pH value of fruits and vegetables, improve the water holding capacity of proteins, promote the softening of food tissue cells, and dissolve the astringent ingredients by boiling and bleaching fruits and vegetables. In addition, it has the effect of removing mutton smell from goat milk, with the dosage of 0.001%~0.002%.

4. Agriculture and animal husbandry use

Sodium bicarbonate can be used for agricultural seed soaking, and it can also make up for the lack of lysine content in the feed. Dissolving sodium bicarbonate in a small amount of water or mixing it into concentrate to feed cattle (add in an appropriate amount) can promote the growth of cattle. It can also significantly increase the milk production of dairy cows.

5. Medical Use

Sodium bicarbonate can be used as a raw material for pharmaceuticals to treat hyperacidity, metabolic acidosis, and to alkalize urine to prevent uric acid kidney stones. It can also reduce the nephrotoxicity of sulfa drugs, prevent hemoglobin deposition in the renal tubules during acute hemolysis, and treat symptoms caused by gastric hyperacidity; intravenous infusion is non-specific for barbiturates, salicylic acid drugs, methanol and other drug poisoning therapeutic effect. However, it is contraindicated in gastric lavage when swallowing strong acidosis, and when a large amount of injection, renal insufficiency or long-term application occurs, arrhythmia, muscle spasm, pain, abnormal fatigue and weakness, slowed breathing, odor in the mouth, frequent urination, urgency, persistent headache, loss of appetite, nausea, vomiting, etc.


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