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Sodium cyclohexane sulfamate is an organic compound with the chemical formula of C6H12NNaO3S. It is a commonly used sweetener, and its sweetness is 30-40 times that of sucrose.
In 1969, it was found that rats fed with saccharin sodium cyclohexane sulfamate had bladder cancer, so in 1970, it was banned in the United States and Japan. In the subsequent study, no carcinogenic effect was found. When the population takes sodium cyclamate, 40% is excreted by urine and 60% is excreted by stool, without accumulation. China's Hygienic Standard for the Use of Food Additives (GB 2760-2014) strictly limits the amount of sodium cyclamate used in food processing.
On October 27, 2017, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization (WHO) was preliminarily sorted for reference, and sodium cyclohexane sulfamate was included in the list of category 3 carcinogens.
It is prepared by sulfonating cyclohexylamine with chlorosulfonic acid or sulfamate to cyclohexylaminosulfonic acid, neutralizing and refining it with sodium hydroxide.
The sweetness of sodium cyclamate is slow, but it lasts for a long time. The sweetness is pure and can be used instead of or mixed with sucrose. Sodium cyclamate can also be mixed with saccharin to mask the bad taste of saccharin. When the ratio of sodium cyclamate to saccharin is 10 ∶ 1, the flavor effect of the product is better. The advantages of sodium cyclamate are better sweetness, lower bitter aftertaste and lower cost than saccharin; The disadvantage is that the sweetness is not high, the dosage is large, and it is easy to exceed the standard.
Sodium cyclohexane sulfamate is an organic compound with the chemical formula of C6H12NNaO3S. It is a commonly used sweetener, and its sweetness is 30-40 times that of sucrose.
In 1969, it was found that rats fed with saccharin sodium cyclohexane sulfamate had bladder cancer, so in 1970, it was banned in the United States and Japan. In the subsequent study, no carcinogenic effect was found. When the population takes sodium cyclamate, 40% is excreted by urine and 60% is excreted by stool, without accumulation. China's Hygienic Standard for the Use of Food Additives (GB 2760-2014) strictly limits the amount of sodium cyclamate used in food processing.
On October 27, 2017, the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization (WHO) was preliminarily sorted for reference, and sodium cyclohexane sulfamate was included in the list of category 3 carcinogens.
It is prepared by sulfonating cyclohexylamine with chlorosulfonic acid or sulfamate to cyclohexylaminosulfonic acid, neutralizing and refining it with sodium hydroxide.
The sweetness of sodium cyclamate is slow, but it lasts for a long time. The sweetness is pure and can be used instead of or mixed with sucrose. Sodium cyclamate can also be mixed with saccharin to mask the bad taste of saccharin. When the ratio of sodium cyclamate to saccharin is 10 ∶ 1, the flavor effect of the product is better. The advantages of sodium cyclamate are better sweetness, lower bitter aftertaste and lower cost than saccharin; The disadvantage is that the sweetness is not high, the dosage is large, and it is easy to exceed the standard.
