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Tetrahydroberberine has strong anti-inflammatory and anti endotoxin shock effects, and the anti-inflammatory mechanism may be related to the inhibition of the exudation of inflammatory substances and the secretion of inflammatory cytokines. The results showed that tetrahydroberberine (human serum oxaline) could significantly improve the survival rate of endotoxic shock mice, and the survival rate of endotoxic shock mice in the 30mg/kg tetrahydroberberine group reached 70%; At the same time, we used ELISA kit to detect the content of TNF in the serum of mice with endotoxic shock; The content of TNF in the serum of mice was significantly increased, and reached the peak at 1h after modeling. The preventive administration of tetrahydroberberine (human hematooxaline) could significantly inhibit the content of TNF I in the serum of mice with endotoxic shock in a dose dependent manner. This result was consistent with that tetrahydroberberine (human hematooxaline) could improve the survival rate of mice with endotoxic shock.
Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces LPS stimulation-induced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 production, and cyclooxygenase-2 (COX-2) activity. Stylopine is the main constituent of the leaves of Chelidonium majus L.
Tetrahydroberberine has strong anti-inflammatory and anti endotoxin shock effects, and the anti-inflammatory mechanism may be related to the inhibition of the exudation of inflammatory substances and the secretion of inflammatory cytokines. The results showed that tetrahydroberberine (human serum oxaline) could significantly improve the survival rate of endotoxic shock mice, and the survival rate of endotoxic shock mice in the 30mg/kg tetrahydroberberine group reached 70%; At the same time, we used ELISA kit to detect the content of TNF in the serum of mice with endotoxic shock; The content of TNF in the serum of mice was significantly increased, and reached the peak at 1h after modeling. The preventive administration of tetrahydroberberine (human hematooxaline) could significantly inhibit the content of TNF I in the serum of mice with endotoxic shock in a dose dependent manner. This result was consistent with that tetrahydroberberine (human hematooxaline) could improve the survival rate of mice with endotoxic shock.
Stylopine ((R,S)-Stylopine, Tetrahydrocoptisine) reduces LPS stimulation-induced nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and IL-6 production, and cyclooxygenase-2 (COX-2) activity. Stylopine is the main constituent of the leaves of Chelidonium majus L.
