Tocofersolan
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Tocofersolan

Product Name:Tocofersolan
Alias: DL-A-TOCOPHEROL POLYETHYLENE GLYCOL SUCCINATE; Vitamin E-TPGS
CAS NO.:9002-96-4
Molecular formula:(C2H4O)nC33H54O5
Storage condition:2-8°C
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Tocofersolan description

Vitamin E polyethylene glycol succinate (TPGS for short) is a water-soluble derivative of vitamin E, which is formed by the reaction between the carboxyl group of vitamin E succinate and the hydroxyl group of polyethylene glycol. Because it contains both vitamin E lipophilic groups and polyethylene glycol hydrophilic long chains, it has good surfactant properties and water solubility, which can significantly increase the absorption of poorly soluble drugs in the gastrointestinal tract and improve the bioavailability.

Tocofersolan properties

Because vitamin E polyethylene glycol succinate contains both vitamin E ester group and polyethylene glycol hydrophilic long chain, it has good surfactant properties and water solubility, it can significantly increase the absorption of insoluble drugs in the gastrointestinal tract, and improve the bioavailability.

Tocofersolan application

Vitamin E polyethylene glycol succinate is now widely used in the research of formulations as solubilizers, absorption enhancers, emulsifiers, plasticizers and carriers for poorly water-soluble or fat-soluble drug delivery systems, such as solid dispersions , carrier for ocular administration, carrier for intranasal administration, etc.

Tocofersolan preparation

Vitamin E polyethylene glycol succinate (TPGS for short) is a water-soluble derivative of vitamin E, which is formed by the reaction between the carboxyl group of vitamin E succinate and the hydroxyl group of polyethylene glycol.

Tocofersolan biological activity

It is a synthetic polyethylene glycol derivative of alpha-tocopherol.


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