Turmeric Root Extract
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Turmeric Root Extract

Product Name:curcuma longa root extract
CAS NO.:84775-52-0
EINECS NO.: 283-882-1

Turmeric Root Extract Introduction

Turmeric extract is the extract of the dried rhizomes of the ginger plant turmeric. The main bioactive substances are curcumin and turmeric, which have the functions of lowering blood pressure, lowering blood lipids, choleretic, antibacterial, anti-inflammatory and antioxidant. Curcumin, a very important pigment compound, it can prevent the automatic oxidation of linoleic acid in food, and has anti-cancer and anti-cancer functions. It has been widely used as a natural high-quality food pigment.

Turmeric Root Extract pharmacological action

1.Turmeric Root Extract Inhibit tumor growth

Turmeric alcohol extract has cytotoxic effect on lymphocytes and Dalton lymphoma cells. Intraperitoneal injection of curcumin liposome preparation can inhibit the generation of Dalton lymphoma cells in mice and increase the survival rate of the mice. 12-O-tetradecanoylphorbolacetate (12-O-tetradecanoylphorbolacetateTPA) is a tumor-promotingagent that can be used to generate skin tumors in mice. For example, TPA combined with curcumin was locally applied to mice twice a week for a total of 20 weeks, and 7,12-dimethylbenz[α]anthracene was used as a tumor initiator in advance, and curcumin could inhibit TPA-produced tumors number.

2.Turmeric Root Extract Gallbladder effect

Turmeric decoction and infusion can increase bile secretion in dogs, make bile components return to normal, and increase gallbladder contraction. Its effect is weak and long-lasting, and can last for 1 to 2 hours. Its choleretic effect is related to its lowering of blood lipids. Curcumin or its sodium salt has a choleretic effect. Intravenous injection in dogs can reduce the content of solid components and increase bile secretion. 50% turmeric decoction promotes appetite.

3.Turmeric Root Extract Anti-peroxidation

Curcumin can significantly antagonize the peroxidation of NIH mouse brain, heart, liver, kidney and spleen homogenate. Within a certain dose range, the intensity of its action is dose-dependent.

4.Turmeric Root Extract Anti-pathogenic microorganisms and protozoa

Turmeric alcohol extract and its active ingredients can inhibit the growth of most pathogens that cause cholecystitis, including Sarcinus, Gaffkya, Corynebacterium, Streptococcus and other bacilli, etc. It is not sensitive to all gram-negative bacilli, some yeasts and molds tested. Turmeric alcohol extract and volatile oil have bactericidal effects, while curcumin is only bacteriostatic to Staphylococcus. Turmeric ether and chloroform extracts have inhibitory effects on several pathogenic dermatophytes in vitro, and 1:10 turmeric volatile oil can inhibit the growth of different pathogenic fungi. Turmeric alcohol extract has anti-tissue amoeba effects in vitro.

5.Turmeric Root Extract Antimutagenic effect

Rats were fed various doses of turmeric (mixed in the feed) for 3 months, and then intraperitoneally injected with benzopyrene or 3-methylcholanthrene. Using Salmonella typhi to detect the mutagenicity of urine, feeding the rats with more than 0.5% turmeric feed can inhibit the mutagenicity of benzopyrene or 3-methylcholanthrene, and turmeric does not affect the feeding and weight gain of the rats , histological examination did not change. Curcumin can inhibit the mutagenicity of several environmental mutagens (cigars, cigarette smoke, tobacco leaves and malt extracts, benzopyrene, dimethyl benzanthracene, etc.), and there is a dose-effect relationship. Curcumin can change Metabolic activation and detoxification of mutagen.

6.Turmeric Root Extract Antibacterial and anti-inflammatory effects

Curcumin and volatile oil have good antibacterial effect on Staphylococcus aureus. Turmeric extract has inhibitory effect on various fungi; curcumin has obvious inhibitory effect on experimental inflammation in mice and rats, it has anti-inflammatory effect on rheumatoid arthritis, and has a certain effect on reducing spermatic cord edema and tenderness.

7.Turmeric Root Extract Anti-fertility effect

Turmeric extract has a pronounced effect on pregnancy termination in mice, rats and rabbits, it antagonizes progesterone activity and contracts the uterus. Experiments show that turmeric decoction and infusion have excitatory effects on isolated uterus and uterine fistula in mice and guinea pigs. The uterine paroxysmal contractions are strengthened, and can be maintained for 5 to 7 hours, showing an anti-pregnancy effect.

8. Turmeric Root Extract Effects on the gastrointestinal tract

Rat gavage with turmeric ethanol extract has obvious anti-ulcer effect on low-temperature restraint stress, pyloric ligation, and ulcers caused by indomethacin and reserpine, and it has obvious protection against gastric injury caused by cyst destroyers effect. Turmeric ethanol extract not only significantly thickened the gastric mucosal wall, but also restored the content of non-protein sulfhydryl groups in the gastric glands of rats.

9.Turmeric Root Extract Effects on the cardiovascular system

Turmeric alcohol extract showed inhibitory effect on frog hearts in vitro and in vivo. Intravenous injection in dogs can cause a drop in blood pressure and arousal breathing. Its antihypertensive effect is not affected by atropine and cutting off the vagus nerve. If the ergot extract is injected first, the antihypertensive effect can be reversed to a boosting effect. Administration of curcumin can increase myocardial nutritional blood flow in mice. Gavage of turmeric extract can resist vasopressin-induced myocardial ischemia in rats.

10. Turmeric Root Extract Lowering blood lipids

Oral administration of turmeric extract, curcumin, and volatile oil can significantly reduce serum cholesterol and β-lipoprotein in experimental hyperlipidemia rats and rabbits, and it can reduce liver cholesterol and correct β- and α-lipoprotein. Disproportionate but no effect on endogenous cholesterol, it also reduces triglyceride and cholesterol levels in the liver of hyperlipidemic rat aortas.

11.Turmeric Root Extract Anticoagulation and inhibition of platelet aggregation

Oral administration of turmeric alcohol extract or curcumin can inhibit ADP-induced platelet aggregation in hyperlipidemia rats. Curcumin enhances fibrinolytic activity. Turmeric ether extract inhibits arachidonic acid-induced human platelet aggregation and thromboxane B2 (TXB2) production, while increasing lipoxygenase-catalyzed products.

12.Turmeric Root Extract Other functions

Turmeric extract and curcumin can enhance fibrinolytic activity, protect liver, and resist liver fibrosis. Turmeric decoction has analgesic effect, and it has analgesic effect on postoperative inflammation and surgical site pain; turmeric decoction has inhibitory effect on hepatitis virus, and has the effect of improving liver parenchymal lesions.