Ursodeoxycholic Acid
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Ursodeoxycholic Acid

Product Name:Ursodeoxycholic Acid
Alias: UDCA
CAS NO.:128-13-2
Molecular formula:C24H40O4
Molecular weight:392.57
Appearance:White powder
EINECS NO.: 204-879-3
Storage conditions: 2-8°C

Ursodeoxycholic Acid introduction

Ursodeoxycholic acid, chemical name 3a, 7 β-  Dihydroxy-5 β-  Cholesterane-24-acid, which is an organic compound, odorless and bitter. In medicine, it is used to increase the secretion of bile acid, change the composition of bile, reduce cholesterol and cholesterol fat in bile, and facilitate the gradual dissolution of cholesterol in gallstones.

Ursodeoxycholic Acid Chemical Properties

This product is white powder; odorless, bitter taste. Mp200-204°C. Soluble in ethanol and glacial acetic acid, soluble in sodium hydroxide solution, insoluble in chloroform. UDCA is an isomer of CDCA, and its litholysis effect is stronger than that of CDCA, without diarrhea and liver toxicity. UDCA can reduce the absorption of cholesterol, and it can reduce the synthesis of cholesterol and the content of cholesterol in bile.

Ursodeoxycholic Acid Purpose

For the treatment of gallstones, cholestatic liver disease, fatty liver, various types of hepatitis, toxic liver disorders, cholecystitis, cholangitis and biliary dyspepsia, bile reflux gastritis, eye diseases, etc.

Ursodeoxycholic acid medicine interactions

(1) When combined with chenodeoxycholic acid, the effect of promoting the reduction of cholesterol content and saturation in bile is greater than that of single drug, and also greater than the additive effect of the two drugs.

(2) This product should not be used in combination with cholestyramine or antacids containing aluminum hydroxide, so as not to affect absorption.

(3) Oral contraceptives can affect the efficacy of this product.

Ursodeoxycholic acid production method

Take 2g of chenodeoxycholic acid, add 100ml of acetic acid, add 20g of potassium acetate, shake to dissolve, add 1.5g of potassium chromate (dissolved in 10ml of water), place at room temperature overnight, add 200ml of water, precipitate crystals, filter, wash, dry, and get 3 α- Hydroxy-7-ketocholic acid. Take 3α- Hydroxy-7-ketocholic acid 4g, add 100ml of n-butanol, heat to about 115 ℃, add 8g of sodium metal in several times, gradually precipitate white paste, continue to react for 30min, add 120ml of water, stir and heat up to dissolve transparent, evaporate the organic layer under reduced pressure, add 500ml of water to the residue, dissolve, filter, add 10% sulfuric acid to adjust pH3, precipitate white floccules, filter, wash to neutral, dry, wash with ethyl acetate, and crystallize with dilute ethanol, get 3α, 7β- Dihydroxycholic acid, namely ursodeoxycholic acid.