Use and Synthesis of Honokiol
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Use and Synthesis of Honokiol

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Magnolol Isomer

Honokiol is the isomer of honokiol, which is a dimer formed by the polymerization of the side chain of one phenylpropanol and the benzene nucleus of another phenylpropanol. It is called neolignan, which is found in many plants of Lauraceae, and is an effective ingredient of the traditional Chinese medicine Magnolia officinalis for antibacterial and anti-inflammatory purposes.

Magnolia Officinalis Extract

Magnolia officinalis, also known as Xiangpu, Chipu, purple oil magnolia officinalis, is a commonly used Chinese medicine. It was first published in Shennong's Classic of Materia Medica and was listed as a Chinese product. Magnolia officinalis extract is a product extracted from the dried root bark, stem bark or branch bark of Magnolia honokiol extract -herb-key

1. Distribution

There are about 90 species of Magnolia plants in the world and about 30 species in China, including about 20 species with medicinal value. Magnolia officinalis is born at the sunny hillside and forest edge with fertile and deep soil at an altitude of 300~1700m.

2. Origin

Magnolia officinalis is mainly distributed in western Hubei, southern Sichuan, southern Shaanxi and southern Gansu; Magnolia officinalis is mainly distributed in Jiangxi, Anhui, Zhejiang, Fujian, Hunan, Guangxi and northern Guangdong. Magnolia officinalis and Magnolia officinalis var. officinalis are widely distributed and cultivated in large areas.

3. Main ingredients

The bark of Magnolia officinalis contains honokiol, honokiol and isohonokiol. Trihydroxy honokiol, deoxy-trihydroxy honokiol, trihydroxy honokiol, polyhonokiol A and C were isolated from the ethyl acetate extract of magnolia officinalis. The bark contains about 1% volatile oil, which mainly contains β- Oleanol; Still included α- Pinene β- Pinene, limonene, bornyl acetate. The bark also contains magnolia curculine. The leaves also contain honokiol and honokiol.

Honokiol Extraction Method

1. Production process of Magnolia officinalis extract (fluid extract)

Take Magnolia officinalis and crush it, soak it with ethanol for 12 hours, put it in a percolation cylinder, percolate with about 12 times the amount of ethanol, collect the percolate, decompress and recover the ethanol to the end, and get the liquid extract. The yield is about 9%, the content of solid is 85.0%, the content of honokiol is more than 11.0%, and the content of honokiol is more than 5.0%.

2. Extraction and separation of honokiol and honokiol

Take the coarse powder of dried bark of Magnolia officinalis, add 1/5 quantity (W/W) of quicklime powder, mix well, and then use 15-20 times quantity of distilled water to percolate, add hydrochloric acid to adjust the pH value of the percolate to 2~3, and leave it still. Collect the precipitate, wash it with distilled water until the pH value of the precipitate is 6-7, add alumina (1:10) after drying, mix it evenly, put it in an extractor, and extract it with cyclohexane. Concentrate the cyclohexane extract, cool it, precipitate white crystals, and filter to obtain crystals and mother liquor. The crystallization is recrystallized with cyclohexane, namely, honokiol. After the mother liquor is concentrated, it precipitates crystals, and cyclohexane is recrystallized to obtain colorless lamellar crystals, which are honokiol crystals. The yield of honokiol was 85%, and that of honokiol was 74%.

Organic Honokiol Application Overview

Magnolia officinalis is a traditional Chinese medicine. It is used in many kinds of prescriptions such as Magnolia officinalis Sanwu Decoction, Pinellia officinalis Houpu Decoction, Dachengqi Decoction, Xiangsha Yangwei Capsule, Huoxiang Zhengqi Water (pill), etc. In recent years, scholars at home and abroad have made in-depth research on the effective ingredients, pharmacodynamics and clinical pharmacy of Magnolia officinalis, and the market has seen the emergence of Magnolia officinalis anti-caries toothpaste, and the antibacterial "chewing gum" prepared by Magnolia officinalis extract.