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This product contains a large amount of fatty oil and protein, and has two kinds of sterols: one is C26H42O2, with a melting point of 288-290°C, which is easily soluble in alcohol; the other is with a melting point of 259-260°C, which is easily soluble in chloroform. It is also said that this product mainly contains two kinds of triterpenoids: betulin and betulinic acid. It also contains jujube saponin, the aglycone is jujube glycoside, and the erbeline lactone obtained by hydrolysis is the second step product of saponin. It also contains a lot of vitamin C.
1. Sedative and hypnotic effects
The total flavonoids and total saponins in Semen Ziziphi spinosae can inhibit the spontaneous activity of mice and cooperate with pentobarbital sodium in sedation and hypnosis, and have sedation and hypnosis effects on rats, mice, cats and other animals.
2. Anticonvulsive effect
To study the effects of Semen Ziziphi spinosae alkaloids on the convulsion latency, death time and mortality of convulsion mice induced by strychnine. It was found that the convulsion time and death time of mice given total alkaloids and cyclic peptide alkaloids of Semen Ziziphi spinosae were significantly prolonged, indicating that Semen Ziziphi spinosae alkaloids had anticonvulsant effects.
3. Anti anxiety effect
The ethanol extract of Semen Ziziphi spinosae has obvious anti anxiety effect, which preliminarily proves that the flavonoid and polysaccharide part of Semen Ziziphi spinosae decoction is the material basis of its anti anxiety effect.
4. Antidepressant effect
Low, medium and high doses of total alkaloids of Semen Ziziphi spinosae were given to mice by gavage. It was found that each dose of total alkaloids could shorten the immobility time of the tail hanging despair model mice, and the false positive antidepressant effect caused by enhancing the spontaneous activity of mice was ruled out through the open field experiment.
5. Anti stress ulcer effect
The formation of stress ulcer is related to the dysfunction of central nervous system. Semen Ziziphi spinosae can balance the process of central excitation and inhibition and improve stress ulcer.
6. Antiarrhythmic effect
The aqueous extract of Semen Ziziphi spinosae has antagonism against arrhythmia induced by aconitine, chloroform, etc., especially it has both preventive and therapeutic effects on arrhythmia caused by aconitine.
7. Prevention and treatment of arteriosclerosis, lowering blood lipid and lowering blood pressure
The total saponins of Semen Ziziphi spinosae can significantly reduce the content of serum total cholesterol, triglyceride and low-density lipoprotein cholesterol in hyperlipidemic rats, increase the content of high-density lipoprotein cholesterol, and regulate the role of blood lipids in hyperlipidemic rats.
8. Analgesic effect
The water extract of Semen Ziziphi spinosae can significantly reduce the convulsion rate and mortality. The hot plate test in mice has obvious analgesic effect.
9. Effect on microcirculation
Semen Ziziphi spinosae could significantly dilate the microvascular diameter.
10. Effect of anti hypoxia ability
The experiment proved that it can significantly reduce the oxygen consumption of brain tissue.
11. Strong anti-tumor effect
The brown extract of Semen Ziziphi spinosae extracted by ethanol can enhance the humoral and cellular immune functions of mice, and has a certain protective effect on radiation injured mice. Ziziphus spinosae seed oil can inhibit the growth of solid tumors in S180 bearing mice, and can significantly increase the spleen index and thymus index of S180 tumorigenic mice.
This product contains a large amount of fatty oil and protein, and has two kinds of sterols: one is C26H42O2, with a melting point of 288-290°C, which is easily soluble in alcohol; the other is with a melting point of 259-260°C, which is easily soluble in chloroform. It is also said that this product mainly contains two kinds of triterpenoids: betulin and betulinic acid. It also contains jujube saponin, the aglycone is jujube glycoside, and the erbeline lactone obtained by hydrolysis is the second step product of saponin. It also contains a lot of vitamin C.
1. Sedative and hypnotic effects
The total flavonoids and total saponins in Semen Ziziphi spinosae can inhibit the spontaneous activity of mice and cooperate with pentobarbital sodium in sedation and hypnosis, and have sedation and hypnosis effects on rats, mice, cats and other animals.
2. Anticonvulsive effect
To study the effects of Semen Ziziphi spinosae alkaloids on the convulsion latency, death time and mortality of convulsion mice induced by strychnine. It was found that the convulsion time and death time of mice given total alkaloids and cyclic peptide alkaloids of Semen Ziziphi spinosae were significantly prolonged, indicating that Semen Ziziphi spinosae alkaloids had anticonvulsant effects.
3. Anti anxiety effect
The ethanol extract of Semen Ziziphi spinosae has obvious anti anxiety effect, which preliminarily proves that the flavonoid and polysaccharide part of Semen Ziziphi spinosae decoction is the material basis of its anti anxiety effect.
4. Antidepressant effect
Low, medium and high doses of total alkaloids of Semen Ziziphi spinosae were given to mice by gavage. It was found that each dose of total alkaloids could shorten the immobility time of the tail hanging despair model mice, and the false positive antidepressant effect caused by enhancing the spontaneous activity of mice was ruled out through the open field experiment.
5. Anti stress ulcer effect
The formation of stress ulcer is related to the dysfunction of central nervous system. Semen Ziziphi spinosae can balance the process of central excitation and inhibition and improve stress ulcer.
6. Antiarrhythmic effect
The aqueous extract of Semen Ziziphi spinosae has antagonism against arrhythmia induced by aconitine, chloroform, etc., especially it has both preventive and therapeutic effects on arrhythmia caused by aconitine.
7. Prevention and treatment of arteriosclerosis, lowering blood lipid and lowering blood pressure
The total saponins of Semen Ziziphi spinosae can significantly reduce the content of serum total cholesterol, triglyceride and low-density lipoprotein cholesterol in hyperlipidemic rats, increase the content of high-density lipoprotein cholesterol, and regulate the role of blood lipids in hyperlipidemic rats.
8. Analgesic effect
The water extract of Semen Ziziphi spinosae can significantly reduce the convulsion rate and mortality. The hot plate test in mice has obvious analgesic effect.
9. Effect on microcirculation
Semen Ziziphi spinosae could significantly dilate the microvascular diameter.
10. Effect of anti hypoxia ability
The experiment proved that it can significantly reduce the oxygen consumption of brain tissue.
11. Strong anti-tumor effect
The brown extract of Semen Ziziphi spinosae extracted by ethanol can enhance the humoral and cellular immune functions of mice, and has a certain protective effect on radiation injured mice. Ziziphus spinosae seed oil can inhibit the growth of solid tumors in S180 bearing mice, and can significantly increase the spleen index and thymus index of S180 tumorigenic mice.
